fMRI技术在脑胶质瘤的应用体会

目的:利用血氧水平依赖法(BOL D)成像对患者脑胶质瘤并可能累及脑皮层功能区的患者进行功能磁共振成像(f MRI)检查,有助于外科治疗方案的制定,以提高手术的成功率和治愈率,避免重要脑功能中枢受到损伤。方法:对12例患有脑胶质瘤的患者用双手对指刺激的方法实行动态MR脑功能成像,共计5 0个动态,每次10个动态,18个层面,扫描时间为15 9s,分别间隔以等时间的静息期,检测感兴趣区正相关系数。结果:12例患者的图像采集满意,激活区均激活边缘系统,丘脑区,激活的脑功能区包括初级和次级躯体感觉区,尤以脑胶质瘤对侧激活最为显著(8例) ,同侧也有部分激活(4例)。结论:左右手对指激活特定的脑功能区,表明患者今后的恢复功能可能是对侧功能的代偿。这对外科制定手术方案,恢复的评估以及避免脑神经功能区的损伤有一定的指导意义。

The Application of fMRI Technique in the Detection of Brain Glioma

Objective To employ Blood-Oxygen-Level-Dependent (BOLD) technique of Function Magnetic Resonance Imaging to detect brain glioma and other glioma-induced braincortex dysfunctions so as to facilitate the formulation of surgery scheme, to increase the effectiveness and efficiency of surgery, and to reduce the possibility of nerve center injury in surgery.Methods Conducted dynamic functional brain imaging on 12 patients with brain glioma while they filliped the other four fingers of one hand with thumb(50 dynamics, 10 for each time; 18 slices; TR 159 seconds; interleaved with the same period of interval); then examined the coefficient of interested regions.Results Data from all the 12 patients were of significance: activated regions were all in brink areas and amic regions; brain activated regions include both primary and secondary somatosensory cortex; areas opposite to the glioma areas in 8 patients shows prominent activation; areas on the same side of the glioma areas also shows some activations.Conclusion Different fingers of left and right hand elicit different brain regions, indicating that the lost function in one damaged brain sphere may be retrieved in its opposite site of another brain sphere, which is very helpful in the for mulation of surgery scheme, to increase the effectiveness and efficiency of surgery, and to reduce the possibility of nerve center injury in surgery.