Blood flow variation and energy metabolism in the gastric mucosa following 7．5％ hypertonic saline resuscitation

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Blood flow variation and energy metabolism in the gastric mucosa following 7. 5% hypertonic saline resuscitation

The study is aimed at examining the effect of the 7. 5% hypertonic saline (HTS) on blood flow and en ergy metabolism in the gastric mucosa after hemorrhagic shock. The experiment was performed on 40 rabbits subjected to rapid hemorrhage (18 ml/kg). At 60 min after hemorrhagic shock,animals were given either HTS or 0. 9% normal saline in a volume 1/4 as much as the shed blood. Blood flow was measured using radioactive microspheres. Adenosine nucleotides were assayed using high performance liquid chromatograph. Resuscitation with HTS caused a significant increase in mean arterial pressure (MAP). At 30 min after HTS infusion.the increase in blood flow at the gastric mucosal layer was more pronounced than that at the gastric muscular layer. A significant rise in levels of ATP with reduced ATPase activity was observed in our study. The results suggest that 7. 5% hypertonic saline solution improved the blood flow and energy metabolism in the gastric mucosa. This effect may help to protect the gastric mucosa against injury caused by local ischemia.