终末期恶性肿瘤患者血浆D二聚体动态变化及意义

目的 了解终末期恶性肿瘤患者血浆D二聚体(D-D)动态变化、探讨其临床意义.方法 观察组125例,均为终末期恶性肿瘤患者,回顾性分析死亡前0～14天内血浆D-D水平,无肿瘤的肠息肉患者63例为照组.15例终末期恶性肿瘤患者死亡前-4周、-3周、-2周、-1周连续测定了血浆D-D,动态分析其变化.结果 观察组死亡前14 ...

Clinical Significanc of Plasma D-dimer Dynamic Changes in End-Stage Malignant Patients

Objective To observe the dynamic changes of plasma D-dimer in end-stage malignant patients and to evaluate its meaning in clinical management.Methods Plasma D-dimer concentration was detected in 125 cases of end-stage malignant patients at the interval of-14 day to death time.63 cases of intestinal polyp patients with exclusion of malignant neoplasm were used as control.To obtain the dynamic changes of plasma D-dimer,15 out of 125 malignant patients with continuous plasma D-dimer detection at the-4,-3,-2 and-1 week was analyzed.Results Plasma D-dimer concentration at the interval between-14 days and death time in end-stage malignant patients was significantly higher as compared with that in the control group(P<0.0001).From-3 week to the death day,Plasma D-dimer level was dynamically increased and the concentration was almost 10 folds higher than the upper limit of normal range.Conclusion The end-stage malignant patients had significantly higher plasma D-dimer level.Dynamic increase of plasma D-dimer concentration with 10 times higher than upper limit of normal range may be a risk factor,which may necessitate prompt and effective management.