老年住院病人血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与衰弱的相关性研究

目的探讨老年住院病人血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平与衰弱的相关性。方法纳入2018年1月至2019年6月老年医学科年龄≥65岁的住院病人195例,进行衰弱表型评估和老年综合评估,采用ELISA法检测血清IGF-1、IGFBP-3水平,分析其与衰弱的相关性。结果与无衰弱、衰弱前期病人相比,衰弱病人血清IGF-1、IGFBP-3水平显著下降,差异有统计学意义(P<0.05)。有序多分类Logistic回归分析显示血清IGF-1(OR=0.943,95%CI0.894~0.994,P<0.05)、IGFBP-3(OR=0.397,95%CI0.259~0.607,P<0.001)水平与衰弱显著相关。结论血清IGF-1、IGFBP-3水平与老年住院病人衰弱显著相关,可能成为老年人衰弱的预测指标。

Association between serum insulin-like growth factor-1,insulin-like growth factor binding protein-3 and frailty in elderly inpatients

Objective To investigate the relationship between serum insulin-like growth factor-1(IGF-1),insulin-like growth factor binding protein-3(IGFBP-3)and frailty in the elderly inpatients.Methods A total of 195 elderly inpatients aged 65 years old and over in the geriatric department were recruited from January 2018 to June 2019.Frailty phenotype assessment and comprehensive geriatric assessment were conducted.The serum levels of IGF-1 and IGFBP-3 were detected by enzyme-linked immunosorbent assay(ELISA).The correlations between IGF-1,IGFBP-3 levels and frailty were analyzed by ordinal multi-factorial Logistic regression.Results Serum levels of IGF-1 and IGFBP-3 in the elderly inpatients with frailty were significantly lower than those in non frailty and pre-frailty groups(P<0.05).Ordered multi-variate Logistic regression analysis showed that the serum levels of IGF-1(OR=0.943,95%CI0.894-0.994,P<0.05)and IGFBP-3(OR=0.397,95%CI0.259-0.607,P<0.001)were significantly correlated with frailty.Conclusions Serum levels of IGF-1 and IGFBP-3 are significantly correlated with frailty in the aged inpatients,and might be used as a predictor for frailty in the aged.