系统性红斑狼疮患儿血清铁蛋白变化及其与病情活动的相关性研究

目的　研究系统性红斑狼疮（SLE）患儿血清铁蛋白（SF）变化及临床意义。方法　研究对象为2004—2009年在南昌大学第二附属医院住院的58例SLE患儿，采用化学发光法检测患儿治疗前和治疗后及30名健康体检儿童的SF。结果　SLE患儿SF显著高于对照组，且活动期SF显著高于静止期。SLE患儿治疗后SF明显下降。SLE患儿SF与抗ds-DNA抗体SLE疾病活动性指标（SLEDAI）评分均呈正相关。结论　SLE患儿的SF较健康儿童显著升高，SF与病情活动性呈正相关，可作为诊断儿童SLE有价值的实验室指标。

Study on the relationship between the serum ferritin levels and disease activity in children with systemic lupus erythematosus.

Objective　To investigate the changes and clinical significance of serum ferritin（SF）levels in children with systemic lupus erythematosus（SLE）. Methods　The serum ferritin levels of 58 children with SLE were measured by Chemiluminescence before and after treatment，and serum ferritin levels were measured in 30 normal children. Results　The serum ferritin levels were significantly higher in children with SLE than those in healthy controls as well as in active children than in inactive children with SLE.And the serum ferritin leveis were significantly decreased after treatment，Moreover， the serum levels of ferritin were positively correlated with anti-ds-DNA antibody levels and SLEDAI（SLE Disease Activity Index）in children with SLE. Conclusion　The serum ferritin levels in children with SLE are significantly higher than those in normal children. Serum ferritin levels aree positively correlated with disease activity in children with SLE.Therefore serum ferritin levers can be a useful laboratory marker to diagnose SLE in children.