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| 阿托伐他汀与辛伐他汀联用致药物性肝损害及磷酸肌酸激酶升高 | |
| 引用本文： | 曲彩红,宋美华,吴瑛,谢虹虹. 阿托伐他汀与辛伐他汀联用致药物性肝损害及磷酸肌酸激酶升高[J]. 中国处方药, 2012, 0(3): 24-26 |
| 作者姓名： | 曲彩红 宋美华 吴瑛 谢虹虹 |
| 作者单位： | 中山大学附属第三医院药学部,广东 广州 510630 |
| 摘 要： | 1例58岁女性患者因行经皮冠状动脉腔内血管成形术( percutaneous translum inalcoronary angioplasty,PTCA)后使用“阿托伐他汀+辛伐他汀”联合降血脂治疗.用药1月后出现乏力,伴轻微肌肉酸痛症状,实验室检查示:ALT 124 U/L,AST 84 U/L,CK 1681 U/L,考虑“药物性肝损害、药物性肌损害”.入院后予停用他汀类降血脂药,并予“还原型谷胱甘肽、苦参碱”护肝、降酶对症治疗,1周后症状明显好转,实验室各项指标接近正常出院. |
| 关 键 词： | 阿托伐他汀 辛伐他汀 药物性肝损害 磷酸肌酸激酶升高 |
Hepatic Lesion and Elevated Phosphocreatinase Induced by Atorvastatin Co-administrated with Simvastatin |
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| QU Cai-hong, SONG Mei-hua, WU Ying, XIE Hong-hong. Hepatic Lesion and Elevated Phosphocreatinase Induced by Atorvastatin Co-administrated with Simvastatin[J]. China Prescription Drug, 2012, 0(3): 24-26 | |
| Authors: | QU Cai-hong SONG Mei-hua WU Ying XIE Hong-hong |
| Affiliation: | (Department of Clinical Pharmacology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China) |
| Abstract: | A 58-year-old woman was treated by "atorvastatin + simvastatin" after percutaneous transluminal coronary angioplasty (PTCA) operation. After treated for 1 month, she developed acratia accompanying with slight muscular soreness. Results of laboratory examination showed ALT 124 U/L, AST 84 U/L, CK 1681 U/L. Drug induced hepatic lesion and elevated phosphocreatinase was suspected. After admission, atorvastatin and simvastatin was suspended, and reduced glutathione, matrine as well as symptomatic treatment was administrated. Symptoms of the patient were improved obviously, results of laboratory examination were access to normal, she was discharged 1 week later. |
| Keywords: | atorvastatin simvastatin drug induced hepatic lesion elevated phosphocreatinase |
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