C反应蛋白和前白蛋白在AECOPD中的临床意义

目的观察AECOPD患者血清C-反应蛋白(C-reactive protein,CRP)、及前白蛋白(preal-bumin,PA)的变化,探讨其与病情严重程度及预后的关系。方法监测152例AECOPD患者入院后第1、3、5、7天CRP和PA水平,根据患者的预后将患者分成死亡与非死亡组,根据住院日数以14日为界分为两组,结果死亡组及非死亡组第1、2天CRP水平差异无统计学意义(P>0.05),第3、5、7天死亡组患者CRP明显高于非死亡组,差异有统计学意义(P<0.05),死亡组PA在第5、7天明显低于非死亡组,差异有统计学意义(P<0.05),结论 AECOPD患者病情越重,CRP水平升高越明显,PA水平呈持续下降趋势。

Clinical significance of C-reactive protein and prealbumin in AECOPD patients

Objective To observe the clinical values of serum C-reactive protein(CRP),and prealbumin(PA) in assessing the severity and the prognosis of AECOPD patient.Methods CRP and PA levels of 152 patients Were measured on the 1st,3rd,5th and 7th day.According to prognosis,the patients were divided into death group and survival group.According to hospital day,the patients were divided into less than 14 days group and more than 14 days group.Result No significant difference was found in the levels of CRP and PA on the 1St and 2nd day(P>0.05),but the levels of CRP in death group were higher than those in survival group on the 3rd,5th and 7th day(P<0.05).The levels of PA in death group was much lower than those in survival group on the 5th and 7th day(P<0.05).Conclusion Continuous high level of CRP and low level of PA indicate unfavourable prognosis and severe diseases of AECOPD patients.