Addition of gentamicine to polymethyl methacrylate for therapy of infectious bone diseases. Expeimental in vivo tests]

In experimental in vivo tests the therapeutic effect of Gentamicin added to Palacos is detected in a standardized osteomyelitic infection caused by Staph. aureus haemolyticus. The number of germ populations is reduced significantly by the antibiotic which is released in a microbiologically active concentration. On the other hand the number of germ populations in control trials (without adding an antibiotic) is remaining on a high level. During the time of the tests the appearance of other bacterial is registrated.