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| 干性年龄相关性黄斑变性患者视网膜色素上皮细胞损伤机制 | |
| 引用本文： | 徐莹,孙晓东. 干性年龄相关性黄斑变性患者视网膜色素上皮细胞损伤机制[J]. 眼科新进展, 2011, 0(7): 692-694,697 |
| 作者姓名： | 徐莹 孙晓东 |
| 作者单位： | 上海交通大学附属第一人民医院眼科; |
| 基金项目： | 国家重点基础研究发展计划973项目(编号:2011CB707506)~~ |
| 摘 要： | 年龄相关性黄斑变性(age-related macular degeneration,AMD)是中老年人视力障碍的重要原因之一。AMD分为2型:萎缩型(干性)和渗出型(湿性)。本文从光照损伤、脂褐素积累、氧化损伤、内质网应激4个方面,综述了干性AMD研究中基于视网膜色素上皮细胞损伤的相关研究进展,为进一步探索其发病机制提供依据和方向。 |
| 关 键 词： | 干性年龄相关性黄斑变性 视网膜色素上皮细胞 发病机制 |
Mechanisms of retinal pigment epithelial cells dysfunction in dry age-related macular degeneration |
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| XU Ying,SUN Xiao-Dong From the. Mechanisms of retinal pigment epithelial cells dysfunction in dry age-related macular degeneration[J]. Recent Advances in Ophthalmology, 2011, 0(7): 692-694,697 | |
| Authors: | XU Ying SUN Xiao-Dong From the |
| Affiliation: | XU Ying,SUN Xiao-Dong From the Department of Ophthalmology,the First Affiliated People's Hospital of Shanghai Jiaotong University,Shanghai 200080,China |
| Abstract: | Age-related macular degeneration(AMD)is one of the leading causes of blindness in middle-aged and elderly people.There are two types of AMD,atrophictype(dry)and exudative type(wet).In order to provide evidence and direction to explore its pathogenesis,we review studies about retinal pigment epithelial cells dysfunction in dry AMD from 4 points of view:light injury,lipofuscin accumulation,oxidative damage and endoplasmic reticulum stress. |
| Keywords: | dry age-related macular degeneration retinal pigment epithelial cells pathogenesis |
| 本文献已被 CNKI 等数据库收录！ | |