DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets |
| |
| Authors: | Qinghua Wu Ragnhild A Lothe Terje Ahlquist Ilvars Silins Claes G Tropé Francesca Micci Jahn M Nesland Zhenhe Suo Guro E Lind |
| |
| Affiliation: | (1) Department of Pathology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway;(2) Department of Cancer Prevention, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway;(3) Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway;(4) Department of Gynecologic Oncology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway;(5) Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway |
| |
| Abstract: | ![]()
Background The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian carcinomas (n = 52) and their in vitro models (n = 4; ES-2, OV-90, OVCAR-3, and SKOV-3) by methylation-specific polymerase chain reaction (MSP). Direct bisulphite sequencing analysis was used to confirm the methylation status of individual genes. The MSP results were compared with clinico- pathological features. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
