| Effects of Glucocorticoid on Electrical Activities of Hippocampal Neurons in vitro |
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| 作者姓名： | 华少莹 陈宜张 |
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| 作者单位： | Hua Shaoying Chen Yizhang Department of Physiology，Second Military Medical College，Shanghai |
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| 基金项目： | Project Supported by the National Natural Science Foundation of China(NSFC) |
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| 摘 要： | Intracellular recording of the rat hippocampal slices was established and usedto analyse the effects of glucocorticoid on resting membrane potential as well as inputresistance of the cells in CA1 and CA2 of hippocampal slices.The results indicate thatwithin 1-2 min the steroid hyperpolarized some of the hippocampal neurons with atendency of increasing the cells' input resistance,suggesting that glucocorticoid caninfluence the function of central neurons in a non-genomic pattern,and the underlyingmechanism involves the change of resting membrane potential.
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Effects of Glucocorticoid on Electrical Activities of Hippocampal Neurons in vitro |
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| Hua Shaoying Chen Yizhang.Effects of Glucocorticoid on Electrical Activities of Hippocampal Neurons in vitro[J].Journal of Medical Colleges of PLA(China),1988(2). |
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| Authors: | Hua Shaoying Chen Yizhang |
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| Institution: | Hua Shaoying Chen Yizhang Department of Physiology,Second Military Medical College,Shanghai |
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| Abstract: | Intracellular recording of the rat hippocampal slices was established and used to analyse the effects of glucocorticoid on resting membrane potential as well as input resistance of the cells in CA1 and CA2 of hippocampal slices.The results indicate that within 1-2 min the steroid hyperpolarized some of the hippocampal neurons with a tendency of increasing the cells' input resistance,suggesting that glucocorticoid can influence the function of central neurons in a non-genomic pattern,and the underlying mechanism involves the change of resting membrane potential. |
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| Keywords: | glucocorticoid hippocampal slice membrane potential cell input resistance |
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