益气养阴活血方对鼻咽癌放疗后涎腺功能的影响

 目的　观察益气养阴活血方治疗放射性涎腺反应的临床疗效。方法　2005年1月至2005年12月对鼻咽癌患者进行了中药治疗放射性涎腺反应的临床研究。治疗组30例患者在放疗期间应用中药益气养阴活血方；对照组30例在放疗期间使用常规处理。结果　两组患者均完成放疗，但对照组中有5例患者放疗过程中曾中止1～2周；急性放射性腮腺改变的发生程度两组差异无统计学意义（χ2 = 2.387，P = 0.122）；两组放射性腮腺改变的发生时间比较，治疗组明显迟于对照组（χ2 = 13.106，P = 0.000）；治疗后两组患者Karnofsky评分比较，治疗组优于对照组（χ2 = 12.685，P = 0.013）；放疗的客观疗效比较，治疗组缓解率90.0 %，对照组86.7 %（χ2 = 0.638，P = 0.727）。结论　益气养阴活血方能减低鼻咽癌放射性涎腺反应临床症候，明显推迟急性放射性反应出现的时间，减轻了患者的痛苦，显著提高鼻咽癌放疗完成率，提高患者的生活质量，中药配合放疗对鼻咽癌有较好的治疗作用。

Effect of Yiqi Yangyin Huoxue decoction on the salivary gland function of the patients with nasopharyngeal carcinoma after the radiotherapy

Objective　Ｔo observe the clinical effect of Yiqi Yangyin Huoxue decoction(the function of decoction is to tonify Qi, nourish Yin and enhance blood circulation) on salivary gland response attribute to radiotherapy. Methods　This study, carried between January 2005 and December 2005, focused on the effect of Chinese herbs on salivary gland response attribute to radiotherapy. In the treatment group, 30 cases took Chinese herbs during the duration of radiotherapy, while in the control group 30 cases were given routine therapy. Results　Both groups had finished the radiotherapy, however, in the control group, there were 5 cas－es with a break for 1~2 weeks. For the comparison of the salivary gland change in acute stage, there was no variance (χ2 = 2.387, P = 0.122); the latency for the salivary gland change in treatment group was longer than that in control group (χ2 = 13.106, P = 0.000). For the comparison of Karnofsky after radiotherapy, the KS was superior in the treatment group than that in control group (χ2 = 12.685, P = 0.013); For the comparison of objective effect after radiotherapy, the remission rate in treatment group was 90 %, and it was 86.7 % in control group(χ2 = 0.638, P = 0.727). Conclusion　The decoction can remit the salivary gland response caused by radiotherapy in clinic, prolong the latency for acute radioactive response; release the pain of the pa－tients, increase the achievement ratio for radiotherapy, and improve the patients' living condition. To combine with radiotherapy, Chinese herbs is a good supplemental therapy for nasopharyngeal carcinoma