| 阿托伐他汀对老年大鼠心肌PPARβ/δ mRNA和MMP-9 mRNA表达水平的影响 |
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| 引用本文： | 韩磊,叶平,刘永学.阿托伐他汀对老年大鼠心肌PPARβ/δ mRNA和MMP-9 mRNA表达水平的影响[J].西北国防医学杂志,2008,29(6). |
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| 作者姓名： | 韩磊 叶平 刘永学 |
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| 作者单位： | 1. 解放军总医院老年心血管二科,北京,100853
2. 军事医学科学院放射医学研究所药理毒理室 |
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| 基金项目： | 北京市自然科学基金
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| 摘 要： | 目的:观察老年大鼠心肌PPARβ/δmRNA和MMP-9 mRNA表达情况及阿托伐他汀的影响。方法:30只20月龄Wister鼠,分为老年对照、大剂量和小剂量阿托伐他汀组。10只3月龄大鼠为青年对照。用RT-PCR检测大鼠心肌PPARβ/δmRNA和MMP-9 mRNA表达水平。结果:①老年大鼠PPARβ/δmRNA表达水平较青年组显著降低(P<0.01),阿托伐他汀可显著上调其表达(P<0.01);②老年大鼠MMP-9 mRNA表达水平较青年组显著增高(P<0.01),阿托伐他汀显著抑制其表达(P<0.01);结论:阿托伐他汀显著抑制老年大鼠心肌MMP-9 mRNA的表达,PPARβ/δ可能参与了这一过程。
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| 关 键 词： | 阿托伐他汀 衰老 过氧化物酶体增殖物激活物受体β/δ |
Effect of atorvastatin on the expressions of PPAR β/δ mRNA and MMP-9 mRNA in myocardium of aging rats |
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| HAN Lei,YE Ping,LIU Yong-xue.Effect of atorvastatin on the expressions of PPAR β/δ mRNA and MMP-9 mRNA in myocardium of aging rats[J].Medical Journal of National Defending Forces in Northwest China,2008,29(6). |
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| Authors: | HAN Lei YE Ping LIU Yong-xue |
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| Institution: | HAN Lei; YE Ping; LIU Yong-xue.(Second Department of Geriatric Cardiology; General Hospital of PLA; Beijing 100853; China); |
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| Abstract: | Objective:To explore the effect of atorvastatin on the expressions of PPAR β/δ mRNA and MMP-9 mRNA in myocardium of aging rats.Methods: Thirty 20-month Wistar rats were divided into aging control group,high-dose atorvastatin group and low-dose atorvastatin group,and ten 3-month Wistar rats as young control group.The expressions of PPAR β/δ mRNA and MMP-9 mRNA were detected by RT-PCR.Results:The expression of PPAR β/δ mRNA in aging rats was significantly lower than that of young rats(P<0.01),and atorvasta... |
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| Keywords: | Atorvastatin Aging Peroxisome proliferator-activated receptor β/δ |
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