| 乌骨藤脂溶性成分抗肿瘤活性及其成分分析 |
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| 引用本文： | 张慧,裴志东,张修亚,康廷国.乌骨藤脂溶性成分抗肿瘤活性及其成分分析[J].中国中药杂志,2010,35(24):3325-3328. |
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| 作者姓名： | 张慧 裴志东 张修亚 康廷国 |
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| 作者单位： | 辽宁中医药大学药学院,辽宁,大连,116600 |
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| 基金项目： | 中国博士后科学基金特别项目(200902550);辽宁省教育厅基金项目(2009T006);大连市科技局青年基金项目(2009J22DW040) |
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| 摘 要： | 目的:研究乌骨藤脂溶性成分的抗肿瘤活性,并分析其化学成分。方法:采用超临界流体萃取法提取中药乌骨藤的脂溶性成分,采用MTT法研究其对人肝癌细胞系HepG-2细胞的细胞毒活性,并利用气相-质谱联用技术分析其化学成分。结果:乌骨藤脂溶性成分对人肝癌细胞系HepG-2细胞有明显的细胞毒活性,同时分析了其化学成分,鉴定了其中24个化合物,并测定了相对含量。结论:乌骨藤的脂溶性成分具有抗肿瘤活性,其药理活性与所含有的化学成分相关。
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| 关 键 词： | 乌骨藤 抗肿瘤活性 化学成分 分析 |
| 收稿时间： | 2010/9/13 0:00:00 |
Antitumor activities of liposoluble components of caulis Marsdeniae tenocissimae and analysis on its chemical constituents |
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| ZHANG Hui,PEI Zhidong,ZHANG Xiuya and KANG Tingguo.Antitumor activities of liposoluble components of caulis Marsdeniae tenocissimae and analysis on its chemical constituents[J].China Journal of Chinese Materia Medica,2010,35(24):3325-3328. |
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| Authors: | ZHANG Hui PEI Zhidong ZHANG Xiuya and KANG Tingguo |
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| Institution: | Department of drug, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;Department of drug, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;Department of drug, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;Department of drug, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China |
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| Abstract: | Objective : To study the antitumor activities of the liposoluble components from caulis Marsdenia tenocissimae and analyze its chemical constituents. Method : The supercritical fluid extraction was used to extract the liposoluble components from caulis M. tenocissimae. MTT test was applied to study the anticancer effects of liposoluble components on growth inhibition in human liver cancer line HepG-2 cells, and the chemical constituents were analyzed by gas chromatography/mass spectrometry (GC-MS). Result : The liposoluble components of caulis M. tenocissimae have obvious growth inhibitory action to HepG-2 cells. Twenty-four compounds were identified and their relative contents were determined. Conclusion : The liposoluble components from caulis M. tenocissimae have antitumor activities, and its pharmacological activity is related to its chemical constituents. |
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| Keywords: | Marsdeniae tenocissimae antitumor activities chemical constituents |
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