| 改进的遗传算法求算药物动力学参数的研究 |
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| 引用本文： | 蔡煜东. 改进的遗传算法求算药物动力学参数的研究[J]. 华西药学杂志, 1996, 11(1): 11-13 |
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| 作者姓名： | 蔡煜东 |
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| 作者单位： | 中科院上海冶金所 |
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| 摘 要： | 对药物动力学参数估计的遗传算法，以一室模型Ｃ（ｔ）＝Ａ（ｅ＾－ｄｔ，－ｅ＾βｔ）为例，尝试了改进的遗传算法的效果，并与文献作了比较，改进的遗传算法性能较，可望成为各类药物动力学参数辨识的有效手段。
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| 关 键 词： | 药物动力学 参数估计 遗传算法 |
THE APPLICATION OF THE IMPROVED GENETIC ALGORITHM TO DETERMINE PARAMETERS IN PHARMACEUTICAL DYNAMICS |
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| Cai Yudong. THE APPLICATION OF THE IMPROVED GENETIC ALGORITHM TO DETERMINE PARAMETERS IN PHARMACEUTICAL DYNAMICS[J]. West China Journal of Pharmaceutical Sciences, 1996, 11(1): 11-13 |
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| Authors: | Cai Yudong |
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| Abstract: | The Improved Genetic algorithm is used to determine the parameters in pharmaceutical dynamics and test its effectiveness with the example of one room model by the comparison with classic approaches in document l.which shows that it operates well and is expected to become an effective tool to the discrimination of various parameters in pharmaceutical dynamics. |
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| Keywords: | Pharmaceutical dynamics The improved genetic algorithm Parameters determination. |
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