Tetraethylammonium-insetisitive,Ca2+-activated whole-cell K+ currents in rat submandibular acinar cells |
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Authors: | Toru Ishikawa Masataka Murakami |
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Affiliation: | (1) Department of Molecular Physiology, National Institute for Physiological Sciences, 444 Okazaki, Japan |
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Abstract: | Using whole-cell patch-clamp techniques, we demonstrate, for the first time, that rat submandibular acinar cells contain a tetraethylammonium (TEA)-insensitive, Ca2+-activated K+ conductance which is not attributable to large conductance, voltage-sensitive, Ca2+-dependent K+ channels (maxi-K+ channels). Taken together with our recent K+ efflux and fluid secretion studies in intact rat submandibular gland, we postulate that the K+ conductance reported here may be involved in the basolateral K+ efflux pathway activated by cytosolic Ca2+ concentration during secretion by this gland. |
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Keywords: | Whole-cell current Ca2+-dependent K+ channels Tetraethylammonium Salivary secretion |
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