红雪茶混合物对小鼠辐射损伤的保护作用

目的 对云南生物资源进行抗辐射保健食品的开发性研究。方法 对云南多种生物资源配方成分进行抗辐射损伤的筛选实验,对其中有作用的红雪茶混合物再进行剂量-效果的观察实验。通过照射前后给予受试物,检测各剂量组受照小鼠的白细胞数、骨髓嗜多染红细胞微核数,观察照射后30 d的平均存活天数。结果 筛选实验表明:红雪茶混合物及螺旋藻混合物具有一定的抗辐射作用。进一步的红雪茶剂量-效应观察试验表明:红雪茶混合物的低、中、高三个剂量均组可降低5 Gy γ射线诱发小鼠骨髓嗜多染红细胞微核发生率;对小鼠白细胞具不同程度的提升作用,对8 Gy受照小鼠30 d存活率在高剂量组有明显保护作用。结论 红雪茶混合物对接受γ射线全身照射小鼠的辐射损伤有一定的保护作用。

Protective Effect of Hong- Xue Tea Mixture Against Radiation Injury in Mice

Objective To develop health food of anti-radition among biological source in Yunnan.Methods Screening test was done of the health food of biological source of anti-radiation injury in mice.It is indicated that Hong-Xue Tea Mixture among the biological source has the effect against radiation injury,observing experiment of dose-effect of Hong-Xue Tea Mixture was done.Micronuclei in the bone marrow polychromatophilic erythrocytes in each dose group of mice were examined,leucocytes number and 30 day survival rate of mice following whole-body 5.0 Gy γirradiation were also determined.Results Research showed that Hong-Xue Tea Mixture and Spirulina Platensis Mixture among the biological source have protective effect against radiation injury in mice.observing experiment of dose-effect of Hong-Xue Tea Mixture show that low,medium and high dose of Hong-Xue Tea Mixture can significantly decrease bone marrow PECMN rate of mice,increase leucocytes number and 30 day survival rate.Conclusion Hong-Xue Tea Mixture has potent protective effects against radiation injury in mice.