人微小病毒B19感染与胃十二指肠疾病的相关性

目的探讨人微小病毒B19感染与胃十二指肠疾病之间的相关性。方法收集139例幽门螺杆菌感染的胃十二指肠疾病患者血液,其中慢性浅表性胃炎65例,消化性溃疡74例;同时收集128例健康体检人群血液作为对照,利用聚合酶链反应法检测两组样本中人微小病毒B19 DNA阳性率。结果 139例胃十二指肠疾病患者中,B19 DNA阳性率为10.07%(14/139),而128例健康体检标本中,B19 DNA阳性率为1.56%(2/128),两组之间差异有统计学意义(P0.01)。比较消化性溃疡组和慢性浅表性胃炎组中B19病毒感染率,结果显示消化性溃疡组病毒阳性率高于慢性浅表性胃炎组(12.16%vs 7.69%),两者与对照组比较差异有统计学意义,但两者间相互比较差异无统计学意义(P0.05)。结论微小病毒B19存在于胃十二指肠疾病患者的血液中,可能与人胃十二指肠疾病的发展密切相关。

Correlation of human parvovirus B19 infection and gastroduodenal diseases

Objective To study the correlation of human parvovirus B19 infection and gastroduodenal diseases.Methods Blood samples of 139 gastroduodenal diseases patients with Helicobacter pylori infection were collected,including65 chronic superficial gastritis cases and 74 peptic ulcer cases,and 128 healthy people as control group.Parvovirus B19-DNA was detected by polymerase chain reaction（PCR）.Results The positive rate of HPV B19-DNA was 10.07%（14/139） in gastroduodenal diseases group,while that in the normal group was 1.56%（2/128）showing statistically significant（P0.01）.The positive rate of HPV B19 infection in peptic ulcer cases was higher than in chronic superficial gastritis and the positive rates in both groups were higher as compared to the control group.Conclusions Human parvovirus B19 existed in the blood of gastroduodenal diseases patients,and may involve in the pathogenesis of disease through the immune responses.