| C-TYPE NATRIURETIC PEPTIDE INHIBITS UPREGULATION OF αl-ADRENOCEPTOR AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT VASCULAR SMOOTH MUSCLE AFTER VASCULAR ENDOTHELIAL INJURY |
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| 引用本文： | 王晓红 杨军佟利家,苏静怡唐朝枢 刘乃奎. C-TYPE NATRIURETIC PEPTIDE INHIBITS UPREGULATION OF αl-ADRENOCEPTOR AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR IN RAT VASCULAR SMOOTH MUSCLE AFTER VASCULAR ENDOTHELIAL INJURY[J]. 中国医学科学杂志(英文版), 2000, 15(2): 73-78 |
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| 作者姓名： | 王晓红 杨军佟利家 苏静怡唐朝枢 刘乃奎 |
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| 作者单位： | InstituteofCardiovascularResearch,theFirstHospital,BeijingMedicalUniversity,Beijing100034 |
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| 摘 要： | Objective. In a model of balloon injury of rat aortic endothelium, the effects of C-type natriuretic peptide(CNP) on al-adrenoreceptar and inositol 1,4,5-triphosphate (IP3) receptor were studied. Methods. Aortic injuries were produced by vascular endothelium-denudation, αl- adrenoreceptor in smooth muscle sarcolemma and IP3 receptor in smooth muscle sarcoplasmic reticulum in the rat aorta were assayed by radioactive analysis method. Results. It was found that neoinfma was formed and the coraents of DNA, collagen and elastin of each intimamedia were significantly increased in 7 days and 21 days after balloon injury of rat aorta, α1-adrenoreceptor in smooth muscle sarcolemma and IP3 receptor in sarcoplasmic reticulum were also upwodated. Results also showed that the administration of CNP i.p significantly decreased the contents of DNA, collagen and elaslin of each iraima-media, and inhibited the up-regulation of α1-adrenoreceptor and IP3 receptor. Conelusion. The inhibition of the up-regulation of α1-adrenoreceptor and IP3 receptor by CNP might be one of the mechanisms of its suppressive action on intimal proliferation.
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| 关 键 词： | CNP IP3 al-肾上腺素受体 IP3受体 血管平滑肌 血管内皮损伤 |
C-TYPE NATRIURETIC PEPTIDE INHIBITSUPR EGULATION OF |
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| Fig .Scatchard transformation inrat aortic smooth muscle sarcolemma d ays after balloon angioplasty. Binding a nalyseswere assessed on separate prep arations from aorta in animals.. C-TYPE NATRIURETIC PEPTIDE INHIBITSUPR EGULATION OF[J]. Chinese medical sciences journal, 2000, 15(2): 73-78 |
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| Authors: | Fig .Scatchard transformation inrat aortic smooth muscle sarcolemma d ays after balloon angioplasty. Binding a nalyseswere assessed on separate prep arations from aorta in animals. |
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| Affiliation: | Institute of Cardiovascular Research, the First Hospital, Beijing Medical University, Beijing 100034. |
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| Abstract: | OBJECTIVE: In a model of balloon injury of rat aortic endothelium, the effects of C-type natriuretic peptide (CNP) on alpha1-adrenoreceptor and inositol 1,4,5-triphosphate (IP3) receptor were studied. METHODS: Aortic injuries were produced by vascular endothelium-denudation. Alpha1-adrenoreceptor in smooth muscle sarcolemma and IP3 receptor in smooth muscle sarcoplasmic reticulum in the rat aorta were assayed by radioactive analysis method. RESULTS: It was found that neointima was formed and the contents of DNA, collagen and elastin of each intima-media were sigificantly increased in 7 days and 21 days after balloon injury of rat aorta. Alpha1-adrenoreceptor in smooth muscle sarcolemma and IF3 receptor in sarcoplasmic reticulum were also upregulated. Results also showed that the administration of CNP i.p. significantly decreased the contents of DNA, collagen and elastin of each intima-media, and inhibited the up-regulation of alpha1-adrenoreceptor and IP3 receptor. CONCLUSION: The inhibition of the up-regulation of alpha1-adrenoreceptor and IP3 receptor by CNP might be one of the mechanisms of its suppressive action on intimal proliferation. |
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