Acute changes in dopamine release and turnover in rat caudate nucleus following a single dose of methamphetamine |
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| Authors: | F. C. Pereira S. Z. Imam B. Gough G. D. Newport C. F. Ribeiro W. Slikker Jr. T. R. Macedo S. F. Ali |
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| Affiliation: | (1) Neurochemistry Laboratory, Division of Neurotoxicology, NCTR, Jefferson, AR, U.S.A., US;(2) Instituto de Farmacologia e Terapêutica, Medical School, University of Coimbra, Portugal, PT |
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| Abstract: | Summary. Acute changes in dopamine (DA) turnover were studied in the caudate nucleus (CN) of adult male rats between 0–24 h after a single injection of Methamphetamine (20 mg/kg, ip). A single dose of METH-induced an increase in DA turnover [(DOPAC + HVA)/DA] concomitant with an acute DA release followed by transient DA and DOPAC depletion in the rat CN. Received February 15, 2002; accepted May 1, 2002 Published online June 28, 2002 |
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| Keywords: | : Methamphetamine acute dosage caudate nucleus microdialysis catecholamines dopamine turnover. |
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