烧伤、冲击伤和烧冲复合伤大鼠肺微血管超微结构病变

为进一步研究烧冲复合伤时肺脏病变的特点,我们制备了大鼠重度冲击伤、15%Ⅲ度烧伤和烧冲复合伤模型,对肺脏微血管的病理变化进行光镜、电镜观察和超微结构定量分析。结果表明,烧伤时肺脏病变主要是肺毛细血管超微结构发生损伤,病变程度较轻。冲击伤和烧冲复合伤时肺微血管损伤均很明显,尤以后者为重,表现为肺水肿增加,血管病变突出,包括小动脉壁结构松散,毛细血管内皮细胞高度肿胀,管腔变窄,血管内大量中性粒细胞聚集等,且病变恢复较慢。提示:上述伤情时微血管损伤是肺脏病变中的主要变化,在防治中应予特别注意。

Ultrastructural changes in pulmonary microvascular damage in rats inflicted with burn,blast and combined burn-blast injury

The pathological changes in pulmonary microvasculature in rats inflicted with overpressure blast,15 % third degree burns and combined burn-blast injury,respec- tively,were studied with electron microscopy and ultrastructural morphometry.Results indicated that the pathological changes in pulmonary microvasculature in 15% third de- gree burns were slight,and mainly restricted to-ultrastructural level.While in severe blast and burn-blast injuries,the damage of pulmonary microvasculature including en- dothelial swelling and regeneration and dispersal of arteriole wall structure,was promi- nent.These changes form the basts of pulmonary hemorrhage and edema.Apart from vessel structural damages,arteriole constriction and capillary closure were also observed during 2 to 4 h postinjury.The vessel damage and dysfunetion were more severe in com- bined injury than in blast injury alone.The mechanisms needed to be studied further.