呋喃丙吡啶对心肌顿抑兔心肌肾素、血管紧张素Ⅱ及去甲肾上腺素的影响

目的研究心肌局部肾素、血管紧张素Ⅱ（ＡｎｇⅡ）及去甲肾上腺素（ＮＥ）在心肌顿抑发病中的作用，以及呋喃丙吡啶（Ｆ３）对心肌顿抑是否具有保护作用。方法采用冠状动脉结扎法建立兔心肌顿抑模型，用放射免疫法测定肾素、ＡｎｇⅡ及ＮＥ的变化，缺血前用呋喃丙吡啶静脉给药。结果心肌缺血后局部肾素活性有升高趋势，再灌注后心肌局部肾素活性显著高于正常对照组。心肌局部ＡｎｇⅡ含量明显高于正常对照组。心肌ＮＥ含量明显升高。缺血前静脉推注呋喃丙吡啶可以降低心肌顿抑时心肌局部ＡｎｇⅡ及ＮＥ的产生。结论心肌局部肾素，ＡｎｇⅡ及ＮＥ在心肌顿抑的发病中具有重要意义，缺血前静脉应用呋喃丙吡啶防治可能是有益的。

1,4-dihydropyridines in the brief postischemic reperfused myocardium of rabbits: Its effects on myocardial renin activity,the content of angiotensin Ⅱ and norepinephrine

AIM To study the pathogenetic roles of heart derived angiotensin Ⅱ (Ang Ⅱ) and norepinephrine (NE) in (stunned myocardium) and cardioprotective effects of calcium antagonist F 3 (1,4 dihydropyridines).METHODS Rabbits were surgically prepared for coronary arterial occlusion and reperfusion. Changes of myocardial renin activity, the content of AngⅡ and NE were observed on the brief postischemic reperfused myocardium in intact rabbits by using RIA. F 3 was used in treatment before ischemia. RESULTS There were significant increase in renin activity and AngⅡ concentrations in stunned myocardium, as compared with those in controls. The NE concentrations of myocardium increased significantly in stunned myocardium ( P< 0 01). Administration of F 3 (3 mg·kg -1 ,Ⅳ) before 15 min in brief ischemia and 15 min reperfusion reduced levels of AngⅡ and NE in the heart dramatically. CONCLUSION The results suggest that heart AngⅡ and NE play important roles in the pathogenesis of brief postischemic reperfused myocardium, F 3 is beneficial to brief postischemic reperfused myocardium.