Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity. |
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| Authors: | J P Karwowski M Jackson M L Maus W L Kohl P E Humphrey P M Tillis |
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| Affiliation: | Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064. |
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| Abstract: | The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity. |
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