28例路易体痴呆患者的视频-多导睡眠图分析 |
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引用本文: | 彭全,施海姗,侯乐,卢慧贤,宁玉萍. 28例路易体痴呆患者的视频-多导睡眠图分析[J]. 神经疾病与精神卫生, 2013, 0(5): 464-467 |
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作者姓名: | 彭全 施海姗 侯乐 卢慧贤 宁玉萍 |
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作者单位: | 东莞东华医院神经内科,523110 |
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基金项目: | 广州市医药卫生科技项目(2012A011070019);广州市医药卫生科技项目(201102A213183);广州市中医药科技项目(201122231038) |
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摘 要: | 目的研究路易体痴呆(DLB)患者的视频~多导睡眠图,探讨路易体痴呆患者的睡眠结构。方法对临床诊断DLB28例及正常对照28人进行研究。所有入组者均进行简易精神状态检查量表(MMSE)和视频~多导睡眠图(Video-PSG)监测。结果(1)睡眠结构分析:与对照组相比,DLB组总睡眠间期时间(SPT)减少,差异具有统计学意义(P〈0.05);总睡眠时间(TST)减少、睡眠效率(SE)下降、总醒觉时间(TWT)、入睡后清醒时间(WASO)增多、1期睡眠时间(TS1)、2期睡眠时间(TS2)、NREM睡眠时间(TNREMS)和REM睡眠时间(TREMS)均明显减少,差异具有统计学意义(P〈0.01);(2)睡眠呼吸事件分析:DLB组与对照组相比,各项指标差异均无统计学意义(P〉0.05);(3)其他睡眠事件分析:与对照组相比,DLB组睡眠期周期性肢体运动次数(PLMS)、快动眼睡眠行为异常(RBD)明显增多,差异具有统计学意义(P〈0.01)。结论DLB患者存在睡眠结构紊乱,睡眠异常行为亦很常见。视频-多导睡眠图对于研究DLB患者的睡眠障碍很有帮助。
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关 键 词: | 路易体痴呆 视频-多导睡眠图 睡眠结构 快动眼睡眠行为异常 |
Analysis of Video-- Polysomnography in dementia with Lewy bodies |
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Affiliation: | PENG Quan, S HI Hai-shan, HOU Le, et al. Department of Neuroscience, Dong Hua Hospital, Guangzhou Medical College, Dong- guan 523110, China |
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Abstract: | Objective To investigate the sleep architecture in dementia with Lewy bodies (DLB). Methods Twenty--eight cases of DLB and 28 cases of normal control were included. All patients re- ceived Mini- mental state examination (MMSE) and video- polysomnographic (PSG) test. Results (1)Sleep architecture analysis: in DLB group, compared with normal control group, the sleep period time (SPT) reduced (P 〈 0.05) ; total sleep time (TST) and sleep efficiency (SE)decreased; totM wake time (TWT) and wake after sleep onset (WASO) increase; 1NREM sleep (TS1), 2NREM sleep (TS2), total NREM sleep (TNREMS) and REM sleep (TREMS) time were significantly decreased (P 〈 0.01). (2) Sleep apnea analysis : no statistical difference was observed (P 〉 0.05). (3) Periodic limb movement disorder (PLMS)and REM sleep behavior disorder (RBD)were more frequent in DLB group. Conclusions DLB patients have a wide range of sleep disorders. Video-- PSG is useful to investi- gate disrupted sleep in DLB. |
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Keywords: | Dementia with Lewy bodies Video--Polysomnography REM sleep behavior dis- order |
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