脑星形细胞瘤中神经细胞粘附分子的表达

目的　研究人脑星形细胞瘤中神经细胞黏附分子的表达情况及其临床意义。方法　收集人脑星形细胞瘤标本 48例 ,行 S— P染色。结果　正常脑组织中 NCAM全部表达 ,星形细胞瘤中 — 级、 级、 级组阳性表达率分别为 95 % (19/2 0 )、38.9% (7/18)、2 0 % (2 /10 ) ,阳性细胞表达程度随肿瘤恶性程度的增高反而降低。结论　随人脑星形细胞瘤恶性程度的增高 ,NCAM表达下调 ,提示 NCAM表达减少参与肿瘤的生物恶性发展

EXPRESSION OF THE NEURAL CELL ADHESION MOLECULE IN HUMAN AS TROCYTOMAS

Objective To investigate the expression of the neural celladhesion mo lecule(NCAM)in human astrocytomas and evaluate the clinic signification.Me thods 48 astrocytomas were studied by S-Pmethod with monoclonal antibody against NCAMprotein.Results All normal brain tissues express NCAM.NC AM expression was positive in 95％(19/20)、38.9％(7/18)、20％(2/10)of Grade Ⅰ- Ⅱ glioma,Grade Ⅲ glioma,Grade Ⅳ glioma respectively.An inverse correation was observed between the deg ree of NCAM expression and the malignancy of these tumors.Coclussion NCAM is down-regulated in the development of the malignancy of astrocytomas;and it is suggested that the reduced NCAM expression might be involved in the deve lopment of biol ogical malignancy.