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| 聚乙二醇硬脂酸酯15对黄芩苷角膜透过性研究 | |
| 引用本文： | 张锐,赵海南,瞿继兰,李琳,李楠,刘志东. 聚乙二醇硬脂酸酯15对黄芩苷角膜透过性研究[J]. 天津中医药大学学报, 2013, 32(1): 36-39 |
| 作者姓名： | 张锐 赵海南 瞿继兰 李琳 李楠 刘志东 |
| 作者单位： | 300193 天津中医药大学,天津市现代中药重点实验室-省部共建国家重点实验室培育基地,现代中药发现与制剂技术教育部工程研究中心 |
| 基金项目： | 国家自然科学基金项目(81001645);中国博士后科学基金项目(20090460701). |
| 摘 要： | [目的]研究聚乙二醇硬脂酸酯15(Sol)对黄芩苷离体角膜透过率的影响,探讨其在眼用制剂中的应用。[方法]采用离体角膜渗透技术考察不同质量浓度的Sol对黄芩苷角膜透过率的影响。[结果]0.4%和0.8%的Sol使黄芩苷的表观渗透系数分别增加了2.05倍和1.65倍,与对照组相比差异有统计学意义(P<0.05),而0.2%、1.0%和2.0%的Sol未能显著增大黄芩苷的表观渗透系数(P>0.05)。[结论]0.4%和0.8%的Sol能够显著增大Sol的表观渗透系数,且对角膜无刺激性。 |
| 关 键 词： | 聚乙二醇硬脂酸酯15 角膜透过性 黄芩苷 |
| 收稿时间： | 2012-12-15 |
Investigation on corneal permeability for Baicalin of SolutolHS 15 in vitro |
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| ZHANG Rui,ZHAO Hai-nan,QU Ji-lan,LI Lin,LI Nan and LIU Zhi-dong. Investigation on corneal permeability for Baicalin of SolutolHS 15 in vitro[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2013, 32(1): 36-39 | |
| Authors: | ZHANG Rui ZHAO Hai-nan QU Ji-lan LI Lin LI Nan LIU Zhi-dong |
| Affiliation: | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China;Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China;Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China;Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China;Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China;Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China |
| Abstract: | [Objective] To investigate the effect of SolutolHS 15 (Sol) on corneal preparation rate and to explore their use in ophthalmology. [Methods] The effects of Sol on the corneal permeability for Baicalin were investigated in vitro with isolated corneas of rabbit. [Results] The 0.4% and 0.8% Sol could increase the appeared permeability for Baicalin as much as 2.05 and 1.65 times respectively when compared with the permeability in control(P<0.05). However, 0.2%, 1.0% and 2.0% Sol could not improve the appeared permeability for Baicalin(P>0.05). [Conclusion] The 0.4% and 0.8% Sol can enhance the corneal appeared permeability for Baicalin significantly and have not irritation on eye tissues. |
| Keywords: | SolutolHS 15 corneal permeability Baicalin |
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