支气管激发试验在咳嗽变异性哮喘诊断中的意义

目的探讨慢性咳嗽及咳嗽变异性哮喘(CVA)患者对支气管激发试验(BPT)的反应情况。方法对553例慢性咳嗽患者进行乙酰甲胆碱支气管激发试验,观察BPT阳性率及CVA阳性率情况。结果 BPT阳性人数207例,阳性率37.4%;最终确诊的CVA为198例,CVA阳性率35.8%。BPT假阳性9例,占4.3%,其中3例为支气管内膜结核。4个不同年龄组别的肺功能指数比较差异无统计学意义(>0.05);男女两组BPT阳性率及CVA百分比差异无统计学意义(>0.05);但<30岁组与≥50岁组相比,前者BPT阳性率要明显高于后者(<0.05)。结论 CVA是构成慢性咳嗽的主要病因之一,对于不明原因的慢性咳嗽患者应及早予BPT检查以提高CVA的诊断率,并给予正确的治疗。

Diagnostic value of bronchial provocation test in patients with cough variant asthma

Objective To observe the response to bronchial provocation test(BPT) in chronic cough patients and cough variant asthma(CVA) patients.Methods Five hundred and fifty three chronic cough patients were enrolled to undertake lung function test and BPT,and BPT and CVA positive rates were observed.Results Two hundred and seven patients were BPT positive,and the positive rate was37.4%;198 patients were diagnosed as CVA,and the positive rate was 35.8%.Nine patients were BPT false positive.Three patients were diagnosed as endobronchial tuberculosis.There was no significant difference of pulmonary function in different age groups(P > 0.05).There was no significant difference of BPT positive rate and CVA positive rate in male and female groups(P > 0.05).The population under 30 years old had the highest BPT positive rate and over 50 years old(including 50 years) population had the lowest positive rate(P < 0.05).Conclusions CVA is the main cause for chronic cough.BPT test can improve the diagnosis rate of CVA and offer the right treatment to patients with chronic cough.