Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate Tablets |
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Authors: | Çiftçi Kadriye Çapan Yilmaz Öztürk Orhan Hincal A Atilla |
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Institution: | (1) Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Hacettepe, 06100, Hacettepe, Ankara, Turkey;(2) Department of Psychiatry, Faculty of Medicine, University of Hacettepe, 06100, Hacettepe, Ankara, Turkey |
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Abstract: | The release of lithium carbonate incorporated into polymethylmethacrylate, poly vinyl chloride, hy-drogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability. |
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Keywords: | lithium sustained release pharmacokinetics bioavailability in vitro |
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