| 月桂氮艹（上）卓（下）酮对青藤碱凝胶剂的透皮吸收作用 |
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| 引用本文： | 张丙宏,张先洲,李杰,蔡海燕,薛承斌.月桂氮艹（上）卓（下）酮对青藤碱凝胶剂的透皮吸收作用[J].中国药学杂志,2002,22(12):707-709. |
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| 作者姓名： | 张丙宏 张先洲 李杰 蔡海燕 薛承斌 |
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| 作者单位： | 1.武汉大学人民医院，湖北武汉430060；2.利川市人民医院，湖北利川
445400；3.武汉大学药学院毕业生，湖北武汉430071 |
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| 基金项目： | 湖北省自然科学基金资助课题（编号2001ABD156） |
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| 摘 要： | 目的:考察不同浓度月桂氮艹（上）卓（下）酮(atone)甘青藤碱凝胶透皮作用的影响，为青藤碱凝胶剂的处方筛选提供依据。方法:采用改良Franz扩散池，以离体大白鼠皮肤为透皮屏障，配制含不同浓度月桂氮艹（上）卓（下）酮的青藤碱凝胶，用HPLC法侧定青藤碱的透皮吸收量。结果:青藤碱凝胶含2% awne时透皮吸收最好，其体外累积渗透量及促透速率最大。青藤碱凝胶剂的体外渗透药动学符合Higuchi方程。结论:选择2% awne作为青藤碱凝胶剂的促透剂。
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| 关 键 词： | 月桂氮艹（上）卓（下）酮 青藤碱凝胶 高效液相色谱法 透皮吸收 |
| 收稿时间： | 2001-07-26; |
Studies on effect of azone on percutaneous absorption of sinomenine gel irc vitro |
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| ZHANG Bing-Hong,ZHANG Xian-Zhou,LI Jie,et al.Studies on effect of azone on percutaneous absorption of sinomenine gel irc vitro[J].Chinese Pharmaceutical Journal,2002,22(12):707-709. |
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| Authors: | ZHANG Bing-Hong ZHANG Xian-Zhou LI Jie |
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| Institution: | Department of Pharmacy, Renmin Hospital of Wuhan university,Hubei Wuhan 430060 |
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| Abstract: | OBJECTIVE To investigate the effect of different content of awne on percutanmus absorption of sinomenine gels in vitro，and to decide an amount of azone for the gel. METHODS The transdermal penetration in Franz diffusion apparatus with ex-cised mice skin of sinomenine gels with different content of azone was studied. The content of sinomenine was determined by HPLC.RESULTS The percutanmus absorption of sinomenine gel containing 2% azone was the best. The permeation process of sinomenine gel in vitro mind be described by Higuchi's Equation. CONCLUSIONS 2% azone is selected as the enhancer of sinomenine gel. |
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| Keywords: | azone sinomenine gels HPLC percutaneous absorption |
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