| 盐酸维拉帕米脉冲释放片体内外释药特性 |
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| 引用本文： | 范辉,周晗瑛,梁文权.盐酸维拉帕米脉冲释放片体内外释药特性[J].中国药学杂志,2002,22(5):271-274. |
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| 作者姓名： | 范辉 周晗瑛 梁文权 |
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| 作者单位： | 1.浙江医科大学附属邵逸夫医院，浙江 杭州 310016；2.浙江大学药学院，浙江 杭州 310006 |
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| 摘 要： | 目的：研究盐酸维拉帕米脉冲释放片体内外释药特性。方法：用干法压制包衣技术制备盐酸维拉帕米脉冲释放片，调整包衣中致孔剂用量，通过体外释放度试验考查时滞，并用HPLC法测定家兔血药浓度，考查体内外时滞的相关性。结果：体内外时滞基本相符。结论：可用体外时滞预测体内的时滞。
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| 关 键 词： | 盐酸维拉帕米 脉冲释药系统 干压包衣片 时滞 控制释放 |
| 收稿时间： | 2001-08-29; |
Study on the in vitro and in vivo drug release of verapamil hydrochroride pulsatile release tablet |
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| FAN Hui,ZHOU Han-Ying,LIANG Wen-Quan,.Study on the in vitro and in vivo drug release of verapamil hydrochroride pulsatile release tablet[J].Chinese Pharmaceutical Journal,2002,22(5):271-274. |
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| Authors: | FAN Hui ZHOU Han-Ying LIANG Wen-Quan |
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| Institution: | Sir Run Run Shao Hospital, Zhejiang Hangzhou 310016 |
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| Abstract: | OBJECTIVE To study the in vitro and in vivo drug release of verapamil hydrochloride pulsatile release tablet.METHODS Verapamil hydrochroride pulsatile release tablet was prepared using convenient dry-coating techniques. A high performance liquid chromatography method was used to determine the plasma concentration of rabbits. The in vitro-in vivo correlation was evaluated.RESULTS There was a good correlation between in vitro and in vivo lag time.CONCLUSIONS The in vivo lag time can be well predicated by in vitro value. |
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| Keywords: | verapamil hydrochloride pulsatile release system dry-coated tablet lag time controlled release |
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