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| 荧光光度法测定硫酸庆大霉素滴眼液在兔眼结膜囊冲洗液中的浓度 | |
| 引用本文： | 刘元元,龚华岳,姚明辉. 荧光光度法测定硫酸庆大霉素滴眼液在兔眼结膜囊冲洗液中的浓度[J]. 中国药学杂志, 2002, 22(10): 595-596 |
| 作者姓名： | 刘元元 龚华岳 姚明辉 |
| 作者单位： | 复旦大学医学院药理教研室，上海 200032；2.上海大江集团股份有限公司生物制药公司，上海 201613 |
| 摘 要： | 目的：比较含有玻璃酸钠的硫酸庆大霉素滴眼液（样品）和硫酸庆大霉素滴眼液（对照）在兔眼结膜囊冲洗液中的浓度。方法：用荧光光度法分别于5,15,30和60 min时测定结膜囊冲洗液中样品和对照的浓度。结果：在60 min内样品的浓度明显高于对照（P<0.01）。结论：样品在结膜囊中能保持较高浓度和维持较长时间。 |
| 关 键 词： | 硫酸庆大霉素 滴眼液 玻璃酸钠 荧光强度 |
| 收稿时间： | 2002-01-30; |
Determination of the concentration of gentamycin sulfate eye drops in rabbits' conjunctival sac washed fluid with fluorescence spectrophotometry |
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| LIU Yuan-Yuan,GONG Hua-Yue,YAO Ming-Hui,. Determination of the concentration of gentamycin sulfate eye drops in rabbits' conjunctival sac washed fluid with fluorescence spectrophotometry[J]. Chinese Pharmaceutical Journal, 2002, 22(10): 595-596 | |
| Authors: | LIU Yuan-Yuan GONG Hua-Yue YAO Ming-Hui |
| Affiliation: | Department of Pharmacology, Medical Center of Fudan University, Shanghai 200032 |
| Abstract: | OBJECTIVE To compare the concentration between gentamycin sulfate eye drops containing sodium hyaluronate(sample) and gentamycin sulfate eye drops(control) in rabbits conjunctival sac.METHODS The sample and the control solution were dropped into rabbits left and right eyes respectively, the concentrations of the drugs in conjunctival sac were determined at 5,15,30 and 60 min respectively with fluorescence spectrophotometer. RESULTS The concentration of the sample solution at 60 min was higher than that of the control solution (P<0.01).CONCLUSIONS The sample solution could remain much higher concentration and maintain longer period in rabbits eyes than that of control solution. |
| Keywords: | gentamycin sulfate eye drops sodium hyaluronate fluorescence intensity conjunctival sac |
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