低分子肝素微囊的制备及其缓释性

 目的：研制低分子肝素缓释微囊。方法：以乙基纤维素为囊材，正交实验设计优选制备工艺，用液中干燥法制备低分子肝素微囊, 以光学显微镜观察其形态及大小分布，体外溶出试验研究其缓释性。结果：所得微囊颗粒圆整，粒径在100～800 μm，载药量为56.3%，8 h累积释放百分率为86.6%。结论：所制得微囊具有良好的缓释效果，有良好的应用开发前景。

Study on preparation of low molecular weight heparin microcapsule and its sustained release property

OBJECTIVE To investigate the preparation of low molecular weight heparin sustained release microcapsule（L-M）.METHODS L-M was prepared through intra-liquid desiccation and the preparing technology of L-M was studied with the orthogonal design，the conformation and size distribution were analysed with microscope,the sustained release behavior was determined in vitro.RESULTS L-M had a globular conformation of 100 and 800 μm with drug content of 56.3%.The accumulated release ratio at 8 h was 86.6%.CONCLUSIONS The sustained release behavior of L-M was remarkable and L-M would have a good exploitation and application.