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| 聚集蛋白聚糖基因多态性与腰椎间盘突出症的关联性 | |
| 引用本文： | 谭平先,李健,孙筱放,颜登鲁,张在恒,张慧敏. 聚集蛋白聚糖基因多态性与腰椎间盘突出症的关联性[J]. 中国组织工程研究与临床康复, 2011, 15(33). DOI: 10.3969/j.issn.1673-8225.2011.33.043 |
| 作者姓名： | 谭平先 李健 孙筱放 颜登鲁 张在恒 张慧敏 |
| 作者单位： | 1. 东莞市常平医院骨科,广东省东莞市,523573;中山大学附属第一医院骨科,广东省广州市,510080 2. 广州医学院第三附属医院,骨科,广东省广州市,510150 3. 广州医学院第三附属医院,妇产科研究室,广东省广州市,510150 |
| 摘 要： | 背景:课题组以往研究表明,中国南方地区汉族人群聚集蛋白聚糖基因存在串联重复序列多态性.目的:观察聚集蛋白聚糖基因多态性与腰椎间盘突出症的关联性.方法:纳入椎间盘突出症患者和非椎间盘突出症患者各51 例.应用聚合酶链反应检测两组聚集蛋白聚糖基因多态性分布情况.采用分层χ2 检验分析聚集蛋白聚糖基因多态性在非椎间盘突出症组合腰椎间盘突出症组之间的分布差异.结果与结论:两组聚集蛋白聚糖基因多态性分布情况检测发现,聚集蛋白聚糖等位基因分布以中等长度串联重复序列片段最多见,短和长串联重复序列片段较少见,两组中出现频率最多的基因型是等位基因27,两组聚集蛋白聚糖等位基因多态性频率分布差异无显著性意义(P > 0.05).在基因型的分布上两组变化趋势基本相同,非椎间盘突出症患者和椎间盘突出症患者分别得出7 和6 种长短不同的串联重复序列.结果证实,聚集蛋白聚糖基因多态性与腰椎间盘突出症尚无明确关联. |
| 关 键 词： | 聚集蛋白聚糖 基因多态性 腰椎 椎间盘突出 骨组织构建 |
Intragenic polymorphisms of the aggrecan associated with lumbar disk herination |
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| Tan Ping-xian,Li Jian,Sun Xiao-fang,Yan Deng-lu,Zhang Zai-heng,Zhang Hui-min. Intragenic polymorphisms of the aggrecan associated with lumbar disk herination[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(33). DOI: 10.3969/j.issn.1673-8225.2011.33.043 | |
| Authors: | Tan Ping-xian Li Jian Sun Xiao-fang Yan Deng-lu Zhang Zai-heng Zhang Hui-min |
| Affiliation: | Tan Ping-xian1,2,Li Jian3,Sun Xiao-fang4,Yan Deng-lu3,Zhang Zai-heng3,Zhang Hui-min4 1Department of Orthopedics,Changping Hospital of Dongguan City,Dongguan 523573,Guangdong Province,China,2Department of Orthopedics,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,3Department of Orthopedics,Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,4Department of Gynaecology and Obstetrics,Third Affiliated Hospital of Gua... |
| Abstract: | BACKGROUND:Previous studies have shown that aggrecan gene in Han population in southern regions in China shows tandem repetitive sequence polymorphism.OBJECTIVE:To investigate the association between aggrecan polymorphism and lumbar disk herniation.METHODS:A total of 102 participants with or without low back pain problem were included in this study.Two groups were used.The study group included 51 lumbar disk herniation participants.The control group included 51 patients without lumbar disk herniation or low... |
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