Survivin及p63蛋白在鳞状细胞癌皮损中的表达及其意义

目的 :研究皮肤鳞癌组织中 Survivin蛋白和 p6 3蛋白的表达及其意义。方法 :采用免疫组化法检测 6 0例皮肤鳞癌组织中 Survivin蛋白和 p6 3蛋白的表达 ,探讨两者与鳞癌组织分化程度的关系。结果 :Survivin蛋白在皮肤鳞癌组织中阳性表达率为 73.3% ,其表达越强 ,组织分化程度越低。 p6 3在高分化鳞癌中呈环状分布于癌巢周围 ,低分化鳞癌中阳性细胞增多 ,分布紊乱 ,其表达在癌的不同分化中差异有显著性。结论 :皮肤鳞癌中 Survivin蛋白的表达与分化程度有密切关系 ,它的高表达提示肿瘤预后不良 ,也可能成为治疗皮肤鳞癌的重要新靶点。 p6 3过度表达的癌细胞是获得了更具增殖、侵袭和间变能力的细胞

Expression and Significance of Survivin and p63 Protein in the Lesions of Skin Squamous Cell Carcinoma

Objective To investingate the expression of Survivin and p63 protein and their significance in skin squamous cell carcin oma.Methods The Survivin and p63 protein expression was detected b y immunohistochemistry in 60 cases of skin squamous cell carcinoma.The relations hip between the expression of these two proteins and tumor grade was analyzed. Results Positive rate of Survivin protein was 73.3 %. Upregulated ex pression of Survivin was strongly associated with poor differentiated.In tighly differentiated tumors ,the staining of p63 formed a ring surrounding carcinoma n ests.In low differentiated tumors,p63-positive cells were increased and disorder ly arranged. A significant correlation between expression of the p63 and skin sq uamous cell carcinoma differentiated was opserved.Conclusion The e xpression of Survivin protein is closely correlated with the differentiation in skin squamous cell carcinoma .Strong expression of Survivin indicates poor pro gnosis and probably become an important target of therapy. Overexpression of p63 may be contributed to acquisition of entanced capabitity of proliferation ,aggr ession and anaplasia in skin squamous cell carcinoma.