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Diagnostics of the neuromyelitis optica spectrum disorders (NMOSD) |
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| Authors: | Diego Franciotta Matteo Gastaldi Arianna Sala Francesca Andreetta Elena Rinaldi Maddalena Ruggieri Rosaria Leante Gianna Costa Tiziana Biagioli Luca Massacesi Elena Bazzigaluppi Raffaella Fazio Sara Mariotto Sergio Ferrari Elisabetta Galloni Francesco Perini Elisabetta Zardini Luigi Zuliani Marco Zoccarato Bruno Giometto Antonio Bertolotto |
| Affiliation: | 1.Laboratory of Neuroimmunology,C. Mondino National Neurological Institute,Pavia,Italy;2.C. Mondino National Neurological Institute,University of Pavia,Pavia,Italy;3.AUO S. Luigi,Orbassano,Italy;4.C. Besta Neurological Institute,Milan,Italy;5.AOU Policlinico di Bari,Bari,Italy;6.Ospedale R. Binaghi,Cagliari,Italy;7.AOU Careggi,Florence,Italy;8.Department of Biomedical, Experimental and Clinical Sciences,University of Florence,Florence,Italy;9.Ospedale San Raffaele,Milan,Italy;10.Department of Neuroscience, Biomedicine and Movement,University of Verona,Verona,Italy;11.Ospedale S. Bortolo,Vicenza,Italy;12.Ospedale Ca’ Foncello AULSS2 Marca Trevigiana,Treviso,Italy;13.Ospedale S.Antonio AULSS Euganea,Padua,Italy |
| Abstract: | This document presents the guidelines for anti-aquaporin-4 (AQP4) antibody testing that has been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on neuromyelitis optica spectrum disorders, indications and limits of anti-AQP4 antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists. |
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