46例癫痫患者发作间期~(18)F-FDG PET显像结果分析

目的　探讨18F 脱氧葡萄糖 (FDG)PET对发作间期癫痫灶的诊断价值。方法　 4 6例癫痫患者于发作间期进行CT和 (或 )MRI、头皮EEG及18F FDGPET检查。结果　 4 6例患者中 86 95 %(40例 )PET显像有异常代谢灶 ,其中低代谢灶 3 1例 ,高代谢灶 9例。而CT和 (或 )MRI仅 5 6 5 2 % (2 6例 )异常 ,EEG 82 60 % (3 8例 )异常。 9例示局限性高代谢区患者 1周后在确认检查前后 12h均未发作的前提下再次行PET检查 ,结果发现其中 7例同一部位出现低代谢区 ,另 2例代谢也有所降低。结论　18F FDGPET对发作间期癫痫灶的诊断价值明显优于CT和 (或 )MRI和头皮EEG ,尤其在发作间期和发作期各检查 1次 ,或延长发作后检查时间 ,可提高灵敏度和特异性及诊断准确性。

The diagnostic value of 18 F FDG PET imaging for interictal epileptic foci

Objective To assess the diagnostic value of 18 F FDG PET imaging for interictal epileptic foci Methods 46 patients with epilepsy were examined interictally with CT/MRI, EEG and 18 F FDG PET Results 40 patients were with significantly abnormal findings in 18 F FDG PET imaging while in CT/MRI 26 were abnormal and in EEG 38 were abnormal Of the 40 patients, 31 showed hypometabolic foci and 9 showed hypermetabolic foci After 1 week, 9 patients with hypermetabolic foci were examined again, among them 7 showed significant hypometabolism in the same area, 2 showed relative hypometabolism of certain extent Conclusions The diagnostic value of 18 F FDG PET imaging for intericatal epileptic foci was higher than that of CT/MRI and EEG in sensitivity; when both ictal and interictal scans were used, and to schedule the inferictal procedure farther from the possible seizure episodes the specificity and accuracy of 18 F FDG PET imaging for the diagnosis of epilepsy could be even better elevated