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| 红景天素抗大鼠心肌衰老作用的实验研究 | |
| 引用本文： | 李颖,崔丽,潘力,栗振宝,纪莉,崔希山. 红景天素抗大鼠心肌衰老作用的实验研究[J]. 中国老年学杂志, 2001, 21(1): 55-57 |
| 作者姓名： | 李颖 崔丽 潘力 栗振宝 纪莉 崔希山 |
| 作者单位： | 1. 吉林大学基础医学院电镜室, 2. 吉林大学第一医院, 3. 长春市朝阳区大屯中心医院药剂科, |
| 摘 要： | 目的：探讨红景天素抗心肌衰老作用。方法：10只雄性Wistar大鼠随机均分为实验组（从第14月龄至24月龄每天定时肌注红景天素1次，15mg/kg体重）和对照组（24月龄）。用化学发光法和TBA法测大鼠血清和心肌中的超氧化物歧化酶（SOD）及过氧化脂质（LPO），用透射电镜观察心肌超微结构的变化。结果：与对照组比较，实验组大鼠血清和心肌中的SOD明显增加，LPO明显减少，实验组大鼠心肌超微结构衰老征象也明显减轻。结论：红景天素具有预防或延缓心肌衰老作用。 |
| 关 键 词： | 心肌衰老 超微结构 红景天素 实验研究 抗衰老作用 |
| 文章编号： | 1005-9202(2001)01-0055-03 |
| 修稿时间： | 1999-10-18 |
Experimental study of anti-ageing effects of rh odosin on myocardium in rats |
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| LI Ying,JI Li,CUI Xi shan et al. Experimental study of anti-ageing effects of rh odosin on myocardium in rats[J]. Chinese Journal of Gerontology, 2001, 21(1): 55-57 | |
| Authors: | LI Ying JI Li CUI Xi shan et al |
| Affiliation: | LI Ying,JI Li,CUI Xi shan et al Department of Electron Microscopy,Basic Medical School of Jilin University,Jilin Changchun 130021 |
| Abstract: | Objective To evaluate the antiagei ng effects of Rhodosin on myocardium.Methods Ten male wistar rats were equally divided into ex perimental group(EG,Rhodosin were I.M.injected at a dose of 15 mg/kg B.W/day during 14～24 months old)and control group(CG,24 months old).content of superoxide dismutase(SOD) in serum and myocardium of rats were determined by ch emiluminecent method and their content of lipid peroxide(LPO) were determined by TBA method.The ultrustructural changes in myocardium of rats were observed by e lectron microscope(EM).Results In comparison with CG,content of SOD of serum and myocardium in EG were markedly increased,and their content of LPO significantly decreased;The ageing features of cell ultrustructure of myocardium in EG were obviously decreased.Conclusions The Rhodosin possesses effects to prevent or prolong ageing of myocardium. |
| Keywords: | Rhodosin Ageing of mocardium Ultrustructure |
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