|
|||||
|
|
| 核酸适配子在疾病诊断研究中的应用 | |
| 引用本文： | 张攀,张焜和. 核酸适配子在疾病诊断研究中的应用[J]. 中南大学学报(医学版), 2014, 39(3): 320-324. DOI: 10.11817/j.issn.1672-7347.2014.03.016 |
| 作者姓名： | 张攀 张焜和 |
| 作者单位： | 南昌大学第一附属医院消化内科,南昌 330006 |
| 基金项目： | 江西省科技支撑计划项目(20133BBG70025);江西省教育厅科技落地计划项目(KJLD13014)。This work was supported by the Science and Technology Pillar Program of Jiangxi Province (20133BBG70025), the Science and Technology Landing Program of Department of Education of Jiangxi Province (KJLD13014), P. R. China. |
| 摘 要： | 核酸适配子是通过指数富集的配体系统进化(systematic evolution of ligands by exponential enrichment,SELEX) 技术从单链随机寡核苷酸文库中筛选得到的单链寡核苷酸配体,其与靶标的结合具有高特异性及高亲和力等优点, 使其能广泛地应用于疾病诊断研究。适配子在生化检测、新肿瘤标志物发现、分子成像、病原微生物检测等领域的 研究应用中均有报道,并显示出良好的应用前景。 |
| 关 键 词： | 适配子 指数富集的配体系统进化 靶标 诊断 |
Nucleic acid aptamers in diagnosis of diseases |
|
| ZHANG Pan,ZHANG Kunhe. Nucleic acid aptamers in diagnosis of diseases[J]. Journal of Central South University. Medical sciences, 2014, 39(3): 320-324. DOI: 10.11817/j.issn.1672-7347.2014.03.016 | |
| Authors: | ZHANG Pan ZHANG Kunhe |
| Affiliation: | Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China |
| Abstract: | Aptamers are single-stranded oligonucleotide ligands selected from a random pool of oligonucleotide sequences by systematic evolution of ligands by exponential enrichment. With the advantages of binding to targets with high specificity and affinity, aptamers have been used in the diagnosis widely, such as biochemistry detection, discovery of new tumor markers, molecular imaging, pathogenic and microorganism detection, showing a good application prospect. |
| Keywords: | aptamer systematic evolution of ligand by exponential enrichment target diagnosis |
| 本文献已被 CNKI 等数据库收录！ | |
| 点击此处可从《中南大学学报(医学版)》浏览原始摘要信息 | |
| 点击此处可从《中南大学学报(医学版)》下载全文 | |