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| 重组人骨形态发生蛋白2在下颌骨牵引成骨过程中的作用 | |
| 引用本文： | 田璐鸣,王稚英. 重组人骨形态发生蛋白2在下颌骨牵引成骨过程中的作用[J]. 中国组织工程研究与临床康复, 2010, 14(15). DOI: 10.3969/j.issn.1673-8225.2010.15.003 |
| 作者姓名： | 田璐鸣 王稚英 |
| 作者单位： | 辽宁医学院附属口腔医院,辽宁省锦州市,121000 |
| 摘 要： | 背景:重组人骨形态发生蛋白2能诱导未分化的间充质细胞不可逆地分化形成软骨和骨,从而导致新骨的形成.目的:观察在下颌骨牵引成骨过程中应用基因重组人骨形态发生蛋白2(rhBMP-2)对成骨的影响.方法:选用日本成年大耳白兔45只,随机分为3组,建立下颌骨牵引模型,分别将空白胶原、1.5mg和3.0mg重组人骨形态发生蛋白2胶原复合物植入下颌骨切开处,固定、牵引0.4 mm/次,2次/d,共计5d,总延长下颌骨4mm.在稳定期第1,3,7,14,28天分别处死各组动物,取牵引区新生骨痂行放射学及组织学检测.结果与结论:重组人骨形态发生蛋白2组中的新生骨组织较空白胶原对照组中多且成熟,3.0mg重组人骨形态发生蛋白2组较1.5 mg重组人骨形态发生蛋白2组新骨形成多且成熟.结果表明,重组人骨形态发生蛋白2能促进兔下颌骨牵引成骨,并且具有浓度依赖性. |
| 关 键 词： | 下颌骨 牵引成骨 基因重组人骨形态发生蛋白2 骨组织工程 |
Effects of recombinant human bone morphogenetic protein 2 on mandibular distraction |
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| Tian Lu-ming,Wang Zhi-ying Affiliated Stomatologial Hospital of Liaoning Medical University,Jinzhou ,Liaoning Province,China. Effects of recombinant human bone morphogenetic protein 2 on mandibular distraction[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2010, 14(15). DOI: 10.3969/j.issn.1673-8225.2010.15.003 | |
| Authors: | Tian Lu-ming Wang Zhi-ying Affiliated Stomatologial Hospital of Liaoning Medical University Jinzhou Liaoning Province China |
| Affiliation: | Tian Lu-ming,Wang Zhi-ying Affiliated Stomatologial Hospital of Liaoning Medical University,Jinzhou 121000,Liaoning Province,China |
| Abstract: | BACKGROUND:Recombinant human bone morphogenetic protein 2(rhBMP-2) can induce undifferentiated mesenchymal cells irreversibly differentiated into cartilage and bone,thus,lead to the formation of new bone.OBJECTIVE:To study the effect of rhBMP-2 on the mandibular distraction.METHODS:A total of 45 Japanese white rabbits were prepared for mandibular distraction models and randomly assigned into control,1.5 mg rhBMP-2 and 3.0 mg rhBMP-2 groups.Collagen sponge and collagen binding proteins were implanted into ma... |
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