血液灌流与持续静脉-静脉血液滤过在治疗百草枯中毒中疗效观察 |
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引用本文: | 李晓萍,蒲友敏,邓朝霞,文亮. 血液灌流与持续静脉-静脉血液滤过在治疗百草枯中毒中疗效观察[J]. 现代医药卫生, 2009, 25(11): 1620-1622 |
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作者姓名: | 李晓萍 蒲友敏 邓朝霞 文亮 |
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作者单位: | 第三军医大学西南医院急救部,重庆,400038 |
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摘 要: | 目的:总结血液灌流(HP)与持续静脉-静脉血液滤过(CVVH)对百草枯(PQ)中毒患者的疗效,以便探讨更加有效的治疗模式。方法:回顾性分析了54例PQ中毒患者,分成对照(常规治疗)组(14例)及试验组(40例),两组均给予常规治疗,试验组加予血液灌流(HP)或CVVH或血液灌流+持续血液滤过(HP+CVVH),比较生存率、死亡生存天数、MODS发生率、肺纤维化发生率的情况。结果:试验组较对照组死亡生存天数明显增加,以HP+CWH组增加最为显著;4h内行HP治疗组的生存率高于4h组,而MODS的发生率降低。结论:CVVH能明显延长PQ中毒患者的生存时间,有效降低早期死亡率,并有望降低整体死亡率;早期、足够的HP治疗能够改善PQ中毒患者的预后,提高生存率;合理的HP及CVVH联合使用有望提高PQ中毒患者的整体救治成功率。
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关 键 词: | 百草枯 中毒 血液灌注 血液滤过 |
Investigation of effect of hemoperfusion,continuous venous-venous hemofiltration on treatment of paraquat poisoning |
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Affiliation: | LI Xiao-ping,PU You-min,DENG Zhao-xia,et al. (Department of Emergency ,Southwest Hospital, Third Military Medical University, Chongqing 400038, China) |
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Abstract: | Objectlve:To investigate the effect of hemopeffusion (HP) and continuous venous-venous hemofidtration (CVVH) on treatment of paraquat poisoning for finding a more effective way of treatment. Methods:To conduct the retrospective analysis of 54 patients admitted with the diagnosis of paraquat poisoning. All patients were given conventional therapy. The control group (n=14) received conventional therapy,the experimental group (n=40) added HP or CVVH or HP+CVVH therapy. Survival rate, living days,MODS rate and pulmonary fibrosis rate between the two groups were analyzed. Results:The living days of the experimental group was more than those of the control group,especially the subset with HP+CVVH had most significant difference.The survival rate was higher in the subset with HP that been given in 4 h than in the subset (HP 〉4h), MODS rate was lower in the former. Conclusion:CVVH can prolong the live time and reduce the mortality rate of earlier period,it would be a hope of reducing total mortality rate.Early and adequate HP is able to improve the prognosis and survival rate. Reasonable use of HP and CVVH would be a way to promote the entire remedy success. |
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Keywords: | Paraquat Poisoning Hemoperfusion Jemofdtration |
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