骨组织工程支架材料：脱矿骨基质

背景：脱矿骨基质是目前研究较多的具备骨诱导及骨引导的生物支架材料之一。 目的：总结脱矿骨基质作为骨组织工程支架材料的研究进展，并展望其发展趋势。 方法：由第一作者检索1965年1月至2013年5月PubMed数据库、中国生物医学数据库、万方数据库及FMJS数据库有关脱矿骨基质及其作为骨组织工程支架材料的相关文献。英文检索词为＂Demineralized Bone Matrix，Scaffold material, Groowth factor, Cells,drugs＂，中文检索词为＂脱矿骨基质，支架材料，生长因子，细胞，药物＂，根据纳入标准排除重复性研究，保留34篇密切相关文献进行归纳总结。 结果与结论：骨组织工程支架材料是组成组织工程骨的主体，而脱矿骨基质既具备骨诱导性又具备骨引导性，可为骨组织细胞的修复提供空间，又可与生物活性因子、活细胞、抗生素等在体外构建成复合体，植入骨内促进骨缺损的愈合。但这一技术也面临着脱矿骨基质与各种物质的配比、消毒、保存成骨活性及抗原性的消除等问题，充分了解脱矿骨基质作为骨组织工程支架的研究，可为其服务于临床提供理论依据。

Demineralized bone matrix as a bone tissue engineering scaffold material

BACKGROUND： Demineralized bone matrix as bone tissue engineering biological scaffold material is more researched currently, which has osteoinductive and osteoconductive.
OBTECTIVE： To summarize the development of demineralized bone matrix as bone tissue engineering scaffold material and to prospect its trend.
METHODS： The relative literatures addressing demineralized bone matrix as bone tissue engineering scaffold material published between January 1965 and May 2013 in PubMed database, Chinese Biomedical Database, Wanfang Database and FMJS database were searched by the first author. The key words were ＂demineralized bone matrix, scaffold material, growth factor, cells, drugs＂ in English and Chinese. According to the inclusion criteria, repetitive researches were excluded, and finally 34 articles were included.
RESULTS AND CONCLUSION： Scaffold material is the key composition of tissue engineered bone, and only demineralized bone matrix has both osteoinductive and osteoconductive properties which cannot only provide space for bone repair, but also can be combined with bioactive factors, living cells, antibiotics in vitro to construct bone graft thereby promoting healing of bone defects. However, this technique is also facing some problems to be solved such as the ratio of demineralized bone matrix and various substances, disinfection, preservation of osteogenetic activity and antigenicity elimination. Sufficiently understanding demineralized bone matrix as bone tissue engineering scaffold can provide a theoretical basis for its clinical service.