兔人工气管移植后成活时间与C-反应蛋白的相关性

背景：研究证实C-反应蛋白在炎症发生及组织损伤时迅速升高，并能提示炎症反应程度。〈br〉 目的：分析实施带支撑环的聚四氟乙烯人工气管替代实验兔颈段气管后成活时间与C-反应蛋白的相关性。方法：用带支撑环聚四氟乙烯人工气管替代实验兔颈段气管，重建气道，观察实验兔气管移植后生存时间，以及实验兔气管移植后第1-7天血清C-反应蛋白的变化。利用简单线性回归分析二者之间的关系。〈br〉 结果与结论：血清C-反应蛋白水平的变化和实验兔生存时间之间呈简单线性相关。生存时间小于13 d的实验兔C-反应蛋白与气管移植后天数呈正相关升高趋势，而生存时间大于13 d的实验兔C-反应蛋白呈负相关降低趋势。正相关兔和负相关兔中位生存时间及95%可信区间（CI）分别为：10 d（95%CI 8.614-11.386 d）和27 d（95%CI 23.970-30.030 d）。负相关样本的生存率明显高于正相关样本（χ2=29.364，P＜0.01）。结果证实实验兔气管移植后生存时间的延长与C-反应蛋白水平的降低有关。

Correlation of survival time and C-reactive protein after artificial tracheal replacement in rabbits

BACKGROUND：C-reactive protein has been shown to rapidly increase during the occurrence of inflammation and tissue injury, and can indicate the degree of inflammatory reaction. OBJECTIVE：To analyze the correlation between survival time and C-reactive protein in rabbits after transplantation of polytetrafluoroethene artificial trachea with support ring.METHODS：The cervical trachea of rabbits was replaced by polytetrafluoroethene artificial trachea with support ring. Survival time of the rabbit, and the changes in serum C-reactive protein at 1-7 days after transplantation were observed. Linear regression was used to assess the univariate association between serum C-reactive protein and survival time. 〈br〉 RESULTS AND CONCLUSION：The linear correlation was observed between changes of serum C-reactive protein and survival time in rabbits with artificial trachea replacement operation. C-reactive protein levels in rabbits with〈13 days of survival time were increased and positively associated with the number of days after transplantation. However, C-reactive protein levels in rabbits with＆gt;13 days were decreased and negatively associated with the number of days after transplantation. In rabbits with positive correlation and negative correlation, the median survival time and 95%confidence interval （CI） were respectively 10 days （95%CI 8.614-11.386 days） and 27 days （95%CI 23.970-30.030 days）. The survival rate in negative correlation group was significantly higher than positive correlation group （χ2=29.364, P〈0.01）. Results suggested that the prolonged survival time of rabbits after artificial trachea replacement operation was related to the decreased concentration of serum C-reactive protein.