| d-儿茶精对乙醇中毒小鼠肝线粒体急性损伤的影响 |
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| 引用本文： | 路雪雅. d-儿茶精对乙醇中毒小鼠肝线粒体急性损伤的影响[J]. 中国药理学与毒理学杂志, 1991, 0(1) |
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| 作者姓名： | 路雪雅 |
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| 作者单位： | 北京中医学院气功研究所生化研究室 北京 |
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| 摘 要： | 本文探讨d-儿茶精对乙醇诱导鼠肝线粒体急性损伤的修复作用。结果证实:该化合物降低模型动物肝线粒体膜脂质膜流动性,增加肝线粒体GSH含量,减少Ca~(2+)的摄取和脂质过氧化物生成。通过对抗乙醇的毒素作用缓解了肝线粒体膜结构的急性损伤。
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| 关 键 词： | d-儿茶精 乙醇 线粒体膜脂质流动性 Ca~(2+)摄取 GSH 脂质过氧化物 |
Effect of d-catechin against acute injury of liver mitochondria membrane in ethanol intoxicated mice |
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| LU Xue-YaBeijing College of Traditional Chinese Medicine,Beijing. Effect of d-catechin against acute injury of liver mitochondria membrane in ethanol intoxicated mice[J]. Chinese Journal of Pharmacology and Toxicology, 1991, 0(1) |
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| Authors: | LU Xue-YaBeijing College of Traditional Chinese Medicine Beijing |
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| Affiliation: | LU Xue-YaBeijing College of Traditional Chinese Medicine,Beijing 100029 |
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| Abstract: | This paper explored effect of mitochondria induced by ethanol. The mechanism of d-catechin on mouse liver acutely injured by orally toxic effect of ethanol on liver mitochondria was dis administrated ethanol. The results confirmed that cussed. d-catechin reduced mitochondria membrane fluidity, increased GSH content, decreased Ca2+ uptake and the production of lipid peroxide in injured liver tissue. This compound delayed acute damage of liver |
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| Keywords: | d-catechin ethanol mitochondria membrane fluidity Ca2+ uptake glutathion lipid peroxidation |
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