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Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetitive transcranial magnetic stimulation |
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| Authors: | Undine E. Lang Malek Bajbouj Juergen Gallinat Rainer Hellweg |
| Affiliation: | (1) Present address: Department of Psychiatry, University of Dresden, Fetscherstr. 74, 01099 Dresden, Germany;(2) Department of Psychiatry, Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany;(3) Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Campus Mitte, Berlin, Germany |
| Abstract: | Background Vagus nerve stimulation (VNS) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques used as therapeutic interventions in major depression.Methods In this study, we report the impact of these stimulation techniques on serum concentrations of brain-derived neurotrophic factor (BDNF) in treatment-resistant patients with a diagnosis of major depression.Results We found no changes of BDNF serum concentrations and no association of neurotrophin concentrations in serum with clinical parameters in our sample.Conclusion Our preliminary results suggest that brain stimulation techniques—in contrast to several antidepressant medications—do not change BDNF serum concentrations. |
| Keywords: | Brain-derived neurotrophic factor (BDNF) Major depression Vagus nerve stimulation (VNS) Transcranial magnetic stimulation (rTMS) |
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