Mercapturic Acid Excretion by Rats following Inhalation Exposure to m1,3-Dichloropropene

Mercapturic Acid Excretion by Rats following Acute InhalationExposure to 1,3-Dichloro-propcne. Fisher, G. D., and Kjlgore,W. W. (1988). Fundam Appl. Toxicol. 11, 300–307. Ratswere exposed to 1,3-dichloropropene (DCP), a commonly used agriculturalnematicide, by inhalation to assess the relationship betweenDCP concentration and the urinary excretion of the mercapturicacid of cis-DCP (3C-NAC). The nose-only exposure system thatwas used for simultaneously exposing up to four rodents is described.This apparatus provided for generation and monitoring of relativehumidity and test vapor concentration. Animals were exposedfor 1 hr to concentrations of up to 789 ppm DCP. Urine was collectedfor 24 hr after exposure. The quantity of 3C-NAC contained inthe urine collections exhibited an exposure concentration-dependentincrease from 0 to 284 ppm DCP. However, the amount of 3C-NACwas no greater for animals exposed to 398 or 789 ppm DCP thanfor animals exposed to 284 ppm DCP. C 1988 Society of Toxicology