| 组织工程骨血管化的研究进展 |
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| 引用本文： | 吴永超. 组织工程骨血管化的研究进展[J]. 国际生物医学工程杂志, 2003, 26(3): 125-128 |
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| 作者姓名： | 吴永超 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院骨科,湖北,武汉,430022 |
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| 摘 要： | 组织工程骨血管化的问题是制约构建大块组织工程骨的一个重要方面 ,迫切需要在材料中构建血管网给种子细胞传输营养物质、氧气和调控因子。血管化可明显促进新生骨的形成 ,材料的性能和三维结构对血管形成有很大的影响 ,成骨细胞和血管内皮细胞共同培养时可以相互促进生长 ,多种细胞因子可以刺激血管的生长并且起协同作用。目前对血管化骨的制备进行了细胞混合培养和使用显微制造技术等一些方法的探索
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| 关 键 词： | 血管形成 骨 组织工程 |
| 文章编号： | 1001-1110(2003)03-0125-04 |
| 修稿时间： | 2002-05-13 |
Development of vascularization of tissue engineering bone |
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| WU Yong chao. Development of vascularization of tissue engineering bone[J]. International Journal of Biomedical Engineering, 2003, 26(3): 125-128 |
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| Authors: | WU Yong chao |
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| Abstract: | Nowadays the vascularization of Tissue Engineering(TE) bone is a obstacle of the development of large size TE bone.It's urgent to construct a blood vessel in TH bone to transport nutrition,oxygen and cell factors.The vascular ization can promote the formation of new bone.The characteristics and construction of matrix materials effect the vascularization,Co culture of osteoblasts and vascular endotheliums has better result than single culture of each kind of cells.Some kinds of cell factors can stimulate the vascualrization and have synergistic actions.Some different methods,such as co culture,vascular pedicle and microfabrication,are on the way to meet the aim of vascularization of TH bone. |
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| Keywords: | vascularization bone tissue engineering |
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