聊城地区尿碘水平与甲状腺疾病的关系

目的探讨聊城地区尿碘水平与甲状腺疾病的关系。方法测定聊城地区甲状腺疾病组和正常对照组的血清TSH、FT3、FT4，甲状腺过氧化物酶抗体（TPOAb），甲状腺球蛋白抗体（TGAb）、甲状腺B超及尿碘。结果正常对照组的尿碘中位数为108μg/L，甲状腺功能异常及甲状腺结节患者的尿碘中位数为263μg／L，显著高于正常对照组，差异有统计学意义（P〈0．01）；在甲状腺功能异常和甲状腺结节患者中，尿碘浓度〉300μg／L者超过50％，高于对照组的35％，差异有统计学意义（P〈0．01）；尿碘与甲状腺功能（FT3、FT4、TSH、TPO、TGA）及甲状腺结节之间无明确的相关性（P〉0．05）。结论聊城地区属碘充足地区，碘过量会增加甲状腺疾病发生率，尿碘测定有助于指导个体化补碘。

Relationship between urinary iodine level and thyroid diseases in Liaocheng

Objective To investigate relationship between urinary iodine level and thyroid diseases in Liaocheng city.Methods Level of serum TSH,FT3,FT4,TPOAb,TGAb and urinary iodine in thyroid disease group and normal control group was detected respectively.Results The median concentration of urinary iodine in normal control group in Liaocheng was 108μg/L.The median urinary iodine level in patients with thyroid dysfunction and thyroid nodal diseases was higher than that in normal control group(P<0.01).In patients with thyroid dysfunction and thyroid nodal diseases,the concentration of urinary iodine Was above 300μg/L and distribution frequency Was much higher than that in control group(P<0.01).There was no correlation between urinary iodine and thyroid function or thyroid nodule(P>0.05).Conclusions Iodine uptake in Liaocheng is sufficient.Additional uptake of iodine increases the incidence of thyroid diseases.Urine iodine detection helps to guide iodine supplementation in individual.