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| 瑞舒伐他汀对代谢综合征病人炎症因子及IR影响 | |
| 引用本文： | 杜英杰,田建会. 瑞舒伐他汀对代谢综合征病人炎症因子及IR影响[J]. 青岛大学医学院学报, 2011, 47(3): 230-231,234 |
| 作者姓名： | 杜英杰 田建会 |
| 作者单位： | 青岛大学医学院附属医院心内科,山东,青岛,266003 |
| 摘 要： | 目的探讨瑞舒伐他汀对代谢综合征(MS)病人超敏C反应蛋白(hs-CRP)、白细胞介素-18(IL-18)及胰岛素抵抗(IR)的影响。方法将40例MS病人随机分为治疗组和对照组。两组均给予降压治疗,同时治疗组给予瑞舒伐他汀10 mg/d治疗。两组治疗6周后检测低密度脂蛋白、高密度脂蛋白、hs-CRPI、L-18、空腹血糖(FBG)、空腹胰岛素水平,计算IR指数。结果治疗组治疗前后各指标比较差异均有显著性(t=4.20~21.19,P<0.05);对照组治疗前后hs-CRP、FBG比较差异有显著性(t=5.53、9.02,P<0.05),余指标治疗前后比较差异无显著性(P>0.05)。两组治疗前后各指标的差值比较差异均有显著性(t=17.28,t′=4.90~20.85,P<0.05)。结论瑞舒伐他汀可降低MS病人的hs-CRPI、L-18的水平,并改善IR。 |
| 关 键 词： | 瑞舒伐他汀 代谢综合征 C反应蛋白 白细胞介素18 胰岛素抵抗 |
EFFECT OF ROSUVASTATIN ON PLASMA LEVEL OF INFLAMMATION FACTORS AND INSULIN RESISTANCE IN PATIENTS WITH METABOLIC SYNDROME |
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| DU YING-JIE,TIAN JIAN-HUI. EFFECT OF ROSUVASTATIN ON PLASMA LEVEL OF INFLAMMATION FACTORS AND INSULIN RESISTANCE IN PATIENTS WITH METABOLIC SYNDROME[J]. Acta Academiae Medicinae Qingdao Universitatis, 2011, 47(3): 230-231,234 | |
| Authors: | DU YING-JIE TIAN JIAN-HUI |
| Affiliation: | DU YING-JIE,TIAN JIAN-HUI(Department of Cardiology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
| Abstract: | Objective To study the effect of rosuvastatin on plasma level of interleukin-18(IL-18),high sensitivity C-reactive protein(hs-CRP),fasting blood glucose(FBG) and fasting insulin(FINS),as well as insulin resistance(IR) in patients with metabolic syndrome(MS).Methods Forty patients with MS were equally randomized to two groups: group A and group B.Patients in both groups were given antihypertensive therapy,at the same time,rosuvastatin was given to those in Group A with a dose of 10 mg,once a day.Plasma level... |
| Keywords: | rosuvastatin metabolic syndrome C-reactive protein interleukin-18 insulin resistance |
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