脑梗死患者D-二聚体、抗心磷脂抗体与脂蛋白（a）的变化及其意义探讨

目的探讨脑梗死患者血清中抗心磷脂抗体(ACA)、D-二聚体(D-Dimer)、脂蛋白a(Lp(a))含量变化与脑梗死的关系和意义。方法采用ELISA法和免疫比浊法测定脑梗死患者63例,疾病对照组65例,正常对照组38例血清中ACA,D-Dimer,Lp(a)的变化特点。结果脑梗死组ACA及ACA-IgG、D-Dimer,Lp(a)含量高于正常对照组(P<0.01)。脑梗死组ACA-IgM与疾病对照组比较差异无显著性意义(P>0.05),疾病对照组ACA及ACA-IgG、ACA-IgM、Lp(a)与正常对照组比较差异无显著性意义(P>0.05)。大面积脑梗死患者的D-Dimer,Lp(a)含量高于小面积脑梗死组(P<0.01,P<0.05)。ACA阳性组D-Dimer,Lp(a)的含量高于ACA阴性组(P<0.01)。结论血中ACA,D-Dimer,Lp(a)的含量变化与脑梗死的发生、发展有密切关系,是脑梗死的重要危险因素,可作为脑梗死诊断、治疗、预后判断的重要实验室指标。

Significance of ACA, D-Dimer and Lipoprotein(a) Alteration in Patients With Cerebral Infarction

Objective To study the clinical significance between the levels of anti-cardiolipin antibodies(ACA),D-Dimer and lipoprotein(a)(Lp(a)) in sera of patients with cerebral infarction.Methods The levels of ACA,D-Dimer and Lp(a) were assessed in 63 patients with cerebral infarction,65 patients with other diseases and 38 healthy controls by ELISA and immunoturbidimitric method.Result Compared with the healthy controls,the levels of ACA,ACA-IgG,D-Dimer,and Lp(a) in sera of patients with cerebral infarction were significantly increased(P<0.01).Compared with the other diseases control group,the difference of positive rate of ACA-IgM was not significant(P>0.05).There was no significant difference in the levels of ACA,ACA-IgG,ACA-IgM,and Lp(a) between the other disease control group and the healthy controls(P>0.05).The levels of D-Dimer and Lp(a) in sera of patients with larger infarction area were significantly higher than those of the patients with smaller infarction area(P<0.01,P<0.05).Conclusion The results suggest that the levels of ACA,D-Dimer and Lp(a) are closely related to existence and development of cerebral infarction.They would be some important risk factors for diagnosis and prevention of cerebral infarction.