| 抗衰汤对血瘀证大鼠肾脏衰老相关基因表达的影响 |
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| 引用本文： | 何赛萍,徐莉.抗衰汤对血瘀证大鼠肾脏衰老相关基因表达的影响[J].浙江中医药大学学报,2011,35(6):892-896. |
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| 作者姓名： | 何赛萍 徐莉 |
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| 作者单位： | 浙江中医药大学 杭州310053 |
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| 基金项目： | 浙江省自然基金课题(NO:Y207747);浙江省卫生厅课题(NO:2006B099)~~ |
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| 摘 要： | 目的]探讨血瘀与衰老的相关性、抗衰汤抗衰老的分子生物学机制,以利中药抗衰老制剂的开发。方法]使用基因芯片技术,确定血瘀影响的衰老基因表达,并考核抗衰汤对血瘀证大鼠衰老相关基因表达谱的影响。结果]确定16个基因为与血瘀相关的衰老基因,但其表达水平受到抗衰汤用药的影响。结论]抗衰汤对与血瘀相关的衰老基因有明显地调控作用,血瘀是导致衰老的关键因素之一。
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| 关 键 词： | 血瘀证 抗衰汤 衰老基因 |
Anti-aging Decoction Influence Kidney Aging-concerned Gene Expression of Rats of Blood Stasis |
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| He Saiping,Xu Li.Anti-aging Decoction Influence Kidney Aging-concerned Gene Expression of Rats of Blood Stasis[J].Journal of Zhejiang University of Traditional Chinese Medicine,2011,35(6):892-896. |
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| Authors: | He Saiping Xu Li |
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| Institution: | Zhejiang Chinese Medical University,Hangzhou(310053) |
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| Abstract: | Objective] To explore relativity between blood stasis and aging,molecular mechanism of Anti-aging Decoction,for development of anti-aging TCM preparation.Method] Apply gene chip technology,define aging gene expression affected by blood stasis,check the influence of Anti-aging Decoction on senile rats’ concerned gene expression spectrum.Result] It defines that 16 genes are related with aging,while the expression level is influenced with Anti-aging Decoction application.Conclusion] Anti-aging Decoction has marked regulation to senile gene related with blood stasis;blood stasis is one key factor of senium. |
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| Keywords: | Anti-aging Decoction blood stasis aging gene |
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